Evidence map›Paper›PMID 40177400›Full record

ArticleMediators of inflammation2025

Strain-Dependent Differences in Inflammatory/Immune Activity in Cutaneous Wound Tissue Repair in Rats: The Significance of Body Mass/Proneness to Obesity.

Jelena B Kulas, Aleksandra D Popov Aleksandrov, Dusanka D Popovic, Anastasija Lj Malesevic, Maja M Cakic Milosevic, Milena V Kataranovski, Ivana I Mirkov, Dina M Tucovic

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jelena B KulasImmunotoxicology Group, Department of Ecology, Institute for Biological Research "Sinisa Stankovic" - National Institute of the Republic of Serbia, University of Belgrade, Belgrade, Serbia.ORCID https://orcid.org/0000-0003-4707-4261
Aleksandra D Popov AleksandrovImmunotoxicology Group, Department of Ecology, Institute for Biological Research "Sinisa Stankovic" - National Institute of the Republic of Serbia, University of Belgrade, Belgrade, Serbia.ORCID https://orcid.org/0000-0002-9081-7481
Dusanka D PopovicImmunotoxicology Group, Department of Ecology, Institute for Biological Research "Sinisa Stankovic" - National Institute of the Republic of Serbia, University of Belgrade, Belgrade, Serbia.ORCID https://orcid.org/0000-0002-0762-2465
Anastasija Lj MalesevicImmunotoxicology Group, Department of Ecology, Institute for Biological Research "Sinisa Stankovic" - National Institute of the Republic of Serbia, University of Belgrade, Belgrade, Serbia.ORCID https://orcid.org/0000-0002-7145-3459
Maja M Cakic MilosevicInstitute of Zoology, Faculty of Biology, University of Belgrade, Belgrade, Serbia.ORCID https://orcid.org/0000-0002-2810-2135
Milena V KataranovskiImmunotoxicology Group, Department of Ecology, Institute for Biological Research "Sinisa Stankovic" - National Institute of the Republic of Serbia, University of Belgrade, Belgrade, Serbia.ORCID https://orcid.org/0000-0002-9368-5613
Ivana I MirkovImmunotoxicology Group, Department of Ecology, Institute for Biological Research "Sinisa Stankovic" - National Institute of the Republic of Serbia, University of Belgrade, Belgrade, Serbia.ORCID https://orcid.org/0000-0001-7115-9340
Dina M TucovicImmunotoxicology Group, Department of Ecology, Institute for Biological Research "Sinisa Stankovic" - National Institute of the Republic of Serbia, University of Belgrade, Belgrade, Serbia.ORCID https://orcid.org/0000-0001-5309-0204

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammatory/immune cells and mediators are substantial for wound healing because they orchestrate biological activities in this complex process. Among factors that affect wound healing, obesity, and metabolic diseases are among the most significant, particularly because of a relationship between obesity and a prediabetic state with immune reactivity. Using Dark Agouti (DA) and Albino Oxford (AO) rats, which differ in immune responses as well as in proneness to obesity, we examined the impact of these intrinsic factors on cutaneous wound healing. Dynamics of the process were monitored at days 3, 5, and 7 post-wounding parallel in both rat strains by analysis of selected basic aspects of the wound repair process (cytokine and growth factor responses) in granulation tissue. Strain-related differences in the extent of reduction of the wound area were shown, which coincided with differential proinflammatory and immune-regulatory cytokines, as well as growth factors response in these rats. Some of these differences seem related to their dissimilarities in the proneness to obesity. Results in this study extended so far known differences in inflammatory/immune responses to a variety of stimuli between AO and DA rats and showed, for the first time, immune-based differences in wound healing between rats that differ in body mass (BM) and obesity proneness (under ad libitum feeding conditions with normal rodent chow).

Indexed as

InflammationObesitySkinWound HealingAnimalsBody WeightCytokinesMaleRatsCytokinescutaneous wound healingimmune/inflammatory activityobesity pronenessrat strains

Identifiers

PMID40177400
PMCPMC11964728

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.