Evidence map›Paper›PMID 40177396›Full record

ArticleACS applied polymer materials2025

Alkyl Chloride-Functionalized Polymers Mediate Oxidation of Thioethers Initiated by Ionizing Radiation.

Juncheng Liu, Irene Piergentili, Bing Xu, Antonia G Denkova, Rienk Eelkema

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied polymer materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Juncheng LiuDepartment of Chemical Engineering, Delft University of Technology, van der Maasweg 9, 2629 HZ Delft, Netherlands.
Irene PiergentiliDepartment of Chemical Engineering, Delft University of Technology, van der Maasweg 9, 2629 HZ Delft, Netherlands.
Bing XuDepartment of Chemical Engineering, Delft University of Technology, van der Maasweg 9, 2629 HZ Delft, Netherlands.
Antonia G DenkovaDepartment of Radiation Science and Technology, Delft University of Technology, Mekelweg 15, 2629 JB Delft, Netherlands.
Rienk EelkemaDepartment of Chemical Engineering, Delft University of Technology, van der Maasweg 9, 2629 HZ Delft, Netherlands.ORCID https://orcid.org/0000-0002-2626-6371

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Irradiation of aqueous solutions containing alkyl chlorides generates peroxyl radicals by reactions of alkyl chlorides, aqueous electrons, and dissolved oxygen. The peroxyl radical can oxidize thioethers to sulfoxides, a transformation that has relevance for targeted or triggered drug delivery. However, small-molecule alkyl chlorides can induce liver damage, which limits their potential for application in anticancer therapy. Here, we show that alkyl chlorides bound to a hydrophilic random copolymer chain behave similar to small-molecule alkyl chlorides. Our work shows that using polymeric alkyl chlorides can be an alternative to small-molecule alkyl chlorides provided that the alkyl chloride functionalities are easily accessible to aqueous electrons.

Identifiers

PMID40177396
PMCPMC11959515

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.