ArticleFrontiers in physiology2025
Analysis of changes in heart rate variability after prolonged ultra-high plateau residence in young healthy population: a cross-sectional study.
Article in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of acute high-altitude exposure on heart rate variability: a systematic review and meta-analysis.Frontiers in physiology · 2025Pooled it
- Role of β-adrenergic signaling in the development of Porphyromonas gingivalis lipopolysaccharide-induced cardiac dysfunction in mice.Scientific reports · 2026Article
- Psychometric Properties of the Chinese Version of the Ford Insomnia Response to Stress Test (FIRST-C) Among Pregnant Women in Qinghai Province, China: A Cross-Sectional Validation Study with Measurement Invariance Testing.International journal of women's health · 2026Article
- Normative data of heart rate variability in healthy populations residing at high altitudes: Influence of age and gender.Journal of family medicine and primary care · 2025Article
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8 authors.
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Abstract
Objective: This study aims to investigate changes in the autonomic nervous system (ANS) by analyzing the characteristics of heart rate variability (HRV). Methods: A portable 3-lead dynamic electrocardiogram monitoring device was used to collect HRV data from the participants. Based on the inclusion and exclusion criteria, a total of 52 volunteers from the Xinjiang Hetian area (ultra-high plateau group, approximately 5300 m altitude) and 56 volunteers from the Sichuan Chengdu area (plain group, approximately 500 m altitude) were enrolled for the 24-hour long-term HRV data collection. A cross-sectional comparison was made between the groups in terms of various HRV time-domain, frequency-domain, and nonlinear indices. The diurnal and nocturnal variations in HRV and ANS after prolonged residence in the ultra-high plateau were further explored by dividing the day into daytime and nighttime periods and calculating the ΔHRV values. Additionally, the participants' heart rate and sleep conditions were analyzed. Results: Compared to the plain group, the ultra-high plateau group showed a significant reduction in overall HRV, with decreased indices of vagal activity (RMSSD, NN50, pNN50, HF, HF norm, and SD1) and increased indices of sympathetic activity (LF norm). The ANS balance indices were increased (LF/HF) and decreased (SD1/SD2), respectively. More importantly, although the diurnal and nocturnal trends of various HRV indices in the ultra-high plateau group were consistent with the plain group, the △HRV value analysis indicated that the ultra-high plateau group had increased △LF (95% CI: 10.20 to 271.60, Conclusion: Prolonged residence in the ultra-high plateau reduces HRV, cardiac reserve capacity, and sleep quality in healthy young adults, diminishes the diurnal recovery capacity of the vagal nerve, and leads to a shift in ANS balance towards reduced vagal activity and enhanced sympathetic activity.
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