Evidence map›Paper›PMID 40177293›Full record

ArticleBioMed research international2025

Erythroferrone-Driven Regulation of Hepcidin and Iron Levels in Polytransfused Sickle Cell Anaemia Patients: A Prospective Study.

Samuel Kwasi Appiah, Charles Nkansah, Godfred Amoah Appiah, Gabriel Abbam, Felix Osei-Boakye, Samira Daud, Kofi Mensah, Safo Adwoa, Korah Seedolf Kuwaahsuore, Emmanuel Yeboah and 11 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Samuel Kwasi AppiahDepartment of Haematology, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana.ORCID https://orcid.org/0000-0003-1855-5840
Charles NkansahDepartment of Haematology, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana.ORCID https://orcid.org/0000-0001-6986-9976
Godfred Amoah AppiahDepartment of Biomedical Laboratory Sciences, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana.
Gabriel AbbamDepartment of Haematology, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana.ORCID https://orcid.org/0000-0002-0408-6126
Felix Osei-BoakyeDepartment of Medical Laboratory Science, Faculty of Health Science and Technology, Ebonyi State University, Abakaliki, Nigeria.ORCID https://orcid.org/0000-0001-5126-7424
Samira DaudDepartment of Haematology, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana.
Kofi MensahDepartment of Haematology, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana.
Safo AdwoaDepartment of Biomedical Laboratory Sciences, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana.
Korah Seedolf KuwaahsuoreDepartment of Biomedical Laboratory Sciences, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana.
Emmanuel YeboahDepartment of Biomedical Laboratory Sciences, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana.
Abu Siraj Salma TiyumbaDepartment of Biomedical Laboratory Sciences, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana.
Dennis ThompsonDepartment of Biomedical Laboratory Sciences, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana.
Viel Mary PaulaDepartment of Biomedical Laboratory Sciences, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana.
Louis Adda DuibajiaDepartment of Biomedical Laboratory Sciences, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana.
Peter TakyiaDepartment of Biomedical Laboratory Sciences, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana.
Franklina Ataa KwartengDepartment of Biomedical Laboratory Sciences, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana.
Obed Odame AsieduDepartment of Biomedical Laboratory Sciences, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana.
Firdaus Ibrahim SukasorrDepartment of Biomedical Laboratory Sciences, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana.
Vincent KawuribiDepartment of Biomedical Laboratory Sciences, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana.
Boniface Nwofoke UkwahDepartment of Medical Laboratory Science, Faculty of Health Science and Technology, Ebonyi State University, Abakaliki, Nigeria.
Ejike Felix ChukwurahDepartment of Medical Laboratory Science, Faculty of Health Science and Technology, Ebonyi State University, Abakaliki, Nigeria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The interplay of erythroferrone (ERFE), hepcidin, and ferroportin is crucial for ensuring systemic iron homeostasis. This study determined the influence of ERFE on hepcidin and iron levels in polytransfused patients with sickle cell anaemia (SCA). This multicentre case-control study recruited 60 SCA participants and 30 controls (HbA), aged 2-34 years, from Tamale Teaching Hospital; Methodist Hospital, Wenchi; and Seventh Day Adventist Hospital, Sunyani, Ghana, between the periods of March to July 2023. About 4 mL of blood was collected for a full blood count using a haematology analyzer and serum ERFE, hepcidin, ferroportin, and ferritin estimation using an enzyme-linked immunosorbent assay. Data were analyzed using SPSS Version 26.0. ERFE (

Indexed as

Anemia, Sickle CellHepcidinsIronAdolescentAdultBlood TransfusionCase-Control StudiesChildChild, PreschoolFemaleFerritinsFerroportinHumansMalePeptide HormonesProspective StudiesErfe protein, humanFerritinsFerroportinHepcidinsIronPeptide Hormoneserythroferroneferroportinhepcidinpolytransfused patientssickle cell anaemiavaso-occlusive crises

Identifiers

PMID40177293
PMCPMC11964725

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.