Evidence map›Paper›PMID 40177291›Full record

ReviewFrontiers in molecular neuroscience2025

Elevated propionate and its association with neurological dysfunctions in propionic acidemia.

Xiaoxin Chen, Qing Cheng, Guo-Fang Zhang

Abstract readReview
In one paragraph

Review in Frontiers in molecular neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Adaptation of White Adipocytes to Cooler Temperatures: Impacts on Energy Metabolism and Protein Acetylation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. [N-carbamylglutamate in the treatment of neonatal organic acidemia crisis: a report of five cases].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Xiaoxin ChenSurgical Research Lab, Department of Surgery, Cooper University Hospital, Cooper Medical School of Rowan University, Camden, NJ, United States.
Qing ChengBiomedical/Biotechnology Research Institute, North Carolina Central University, Durham, NC, United States.
Guo-Fang ZhangSarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University, Durham, NC, United States.

Funding

Understanding Perceptions of HIV Risk, PrEP, and PrEP use among African American Women Attending an HBCUU54MD012392 · NIMHD · NORTH CAROLINA CENTRAL UNIVERSITY · PI Kevin Sean Kimbro · 2017 to 2026
$38.1M
Research Education Component CoreP30AG072958 · NIA · DUKE UNIVERSITY · PI Heather E. Whitson · 2021 to 2026
$24.1M
NRF2-ACSS2 Axis in Alcohol-induced Metabolic Reprogramming and Esophageal PathologyR01AA030026 · NIAAA · CORIELL INSTITUTE FOR MEDICAL RESEARCH · PI XIAOXIN Luke CHEN, Guofang Zhang · 2022 to 2026
$2.9M
Triacetin Treatment for Propionic Acidemia by Rebalancing the Acetyl-CoA/Propionyl-CoA MetabolismR21TR005163 · NCATS · DUKE UNIVERSITY · PI CHEN, XIAOXIN LUKE, ZHANG, GUOFANG · 2024 to 2025
$431k
Pipeline in Aging Research Career Training (PACT)R25AG086122 · NIA · GEORGETOWN UNIVERSITY · PI BLANCATO, JAN K, LI, P. ANDY · 2024 to 2024
$409k
NCATS NIH HHS R21 TR005163NIAAA NIH HHS R01 AA030026NIA NIH HHS P30 AG072958NIA NIH HHS R25 AG086122NIMHD NIH HHS U54 MD012392
6 · The paper itself

Abstract

Propionate, a short-chain fatty acid (SCFA), has recently attracted attention for its various health benefits. However, elevated levels of propionate in certain pathological conditions can have adverse effects. Propionic acidemia (PA) is a rare metabolic disorder caused by mutations in the propionyl-CoA carboxylase (PCC) gene (

Indexed as

metabolismmicrobiomeneurological dysfunctionpropionatepropionic acidemiarare metabolic diseasesshort-chain fatty acids

Identifiers

PMID40177291
PMCPMC11962025

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.