Evidence map›Paper›PMID 40177290›Full record

ArticlemicroPublication biology2025

A commonly used anti-SOX15 antibody fails to demonstrate specificity in mouse embryos.

Farina Aziz, Bin Gu, Amy Ralston

Abstract read
In one paragraph

Article in microPublication biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Farina AzizCell and Molecular Biology Program, Michigan State University, East Lansing, MI, USA.
Bin GuDepartment of Obstetrics, Gynecology and Reproductive Biology, Michigan State University, East Lansing, MI, USA.
Amy RalstonDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA.

Funding

Signaling-regulated establishment of pluripotency in vivoR01HD108722 · NICHD · MICHIGAN STATE UNIVERSITY · PI Amy Ralston · 2023 to 2026
$2.4M
NICHD NIH HHS R01 HD108722
6 · The paper itself

Abstract

SOX15 is a broadly conserved transcription factor involved in many critical processes, including mammalian cell fate specification and pluripotency. We investigated the specificity of a commercially available, polyclonal anti-SOX15 antibody advertised as knockout-validated. We generated a new mouse line carrying a null allele of

Identifiers

PMID40177290
PMCPMC11962655

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.