ArticleFrontiers in medicine2025
The association between lipid accumulation product and osteoporosis in American adults: analysis from NHANES dataset.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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8 authors.
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Abstract
Background: The Lipid Accumulation Product (LAP), a novel indicator of fat accumulation, reflects the distribution and metabolic status of body fat. This study aims to evaluate the relationship between adult Americans' prevalence of osteoporosis and LAP. Methods: This study used data from the NHANES cycles 2007-2010, 2013-2014, and 2017-2018, including 4,200 adults aged 50 and above. LAP was calculated using waist circumference and triglyceride levels, whereas osteoporosis was identified using information from dual-energy X-ray absorptiometry (DXA) assessments of bone mineral density (BMD). Restricted cubic spline (RCS) analysis was evaluated the relationship between LAP and osteoporosis. Additionally, subgroup analyses were conducted to assess the impact of demographic characteristics and health status on the relationship between LAP and osteoporosis. Results: LAP and osteoporosis were shown to be significantly inversely correlated in the study. In the unadjusted model, the prevalence of osteoporosis and Log LAP showed a significant negative connection (OR = 0.62, 95% CI = 0.52-0.74). Osteoporosis prevalence decreased by 45% in the fully adjusted model for every unit rise in Log LAP (OR = 0.54, 95% CI = 0.44-0.66). RCS analysis revealed a nonlinear association between LAP and osteoporosis prevalence ( Conclusion: According to this study, there is a substantial negative relationship between adult prevalence of osteoporosis in America and LAP. LAP is an easy-to-use and practical indication that may be very helpful in osteoporosis prevention and early detection.
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