Evidence map›Paper›PMID 40177269›Full record

ArticleFrontiers in medicine2025

Experimental and theoretical studies on structural changes in the microtubule affinity-regulating kinase 4 (MARK4) protein induced by

Ashanul Haque, Khalaf M Alenezi, Mohd Saeed Maulana Abdul Rasheed, Md Ataur Rahman, Saleha Anwar, Shahzaib Ahamad, Dinesh Gupta

Abstract read
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In one paragraph

Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ashanul HaqueDepartment of Chemistry, College of Science, University of Hail, Hail, Saudi Arabia.
Khalaf M AleneziDepartment of Chemistry, College of Science, University of Hail, Hail, Saudi Arabia.
Mohd Saeed Maulana Abdul RasheedDepartment of Biology, College of Science, University of Hail, Hail, Saudi Arabia.
Md Ataur RahmanChemistry Program, New York University Abu Dhabi (NYUAD), Saadiyat Island, Abu Dhabi, United Arab Emirates.
Saleha AnwarCentre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India.
Shahzaib AhamadTranslational Bioinformatics Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India.
Dinesh GuptaTranslational Bioinformatics Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Alzheimer's disease (AD) is a neurodegenerative disorder that progressively affects the cognitive function and memory of the affected person. Unfortunately, only a handful of effective prevention or treatment options are available today. Microtubule affinity-regulating kinase 4 (MARK4) is a serine/threonine protein that plays a critical role in regulating microtubule dynamics and facilitating cell division. The dysregulated expression of MARK4 has been associated with a range of diseases, including AD. Methods: In this study, we synthesized a series of Results: Six new 4-(6-(arylpyrimidin-4-yl)piperazine-1-carboximidamides Conclusion: We demonstrated that 4-(6-(arylpyrimidin-4-yl)piperazine-1-carboximidamides) are a promising class of

Indexed as

Alzheimer’s diseasekinase inhibitormolecular dockingmolecular dynamicspyrimidine derivativesSuzuki-Miyaura coupling

Identifiers

PMID40177269
PMCPMC11962044

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.