Evidence map›Paper›PMID 40177265›Full record

ArticleBioinformatics advances2025

Biological databases in the age of generative artificial intelligence.

Mihai Pop, Teresa K Attwood, Judith A Blake, Philip E Bourne, Ana Conesa, Terry Gaasterland, Lawrence Hunter, Carl Kingsford, Oliver Kohlbacher, Thomas Lengauer and 12 more

Abstract readEditorial
In one paragraph

Article in Bioinformatics advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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  3. Article
  4. Review
  5. Article
  6. Article
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  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Mihai PopCenter for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, United States.ORCID https://orcid.org/0000-0001-9617-5304
Teresa K AttwoodDepartment of Computer Science, The University of Manchester, Manchester M13 9PL, United Kingdom.ORCID https://orcid.org/0000-0003-2409-4235
Judith A BlakeThe Jackson Laboratory, Bar Harbor, ME 04609, United States.ORCID https://orcid.org/0000-0001-8522-334X
Philip E BourneSchool of Data Science, The University of Virginia, Charlotesville, VA 22904, United States.
Ana ConesaInstitute for Integrative Systems Biology, Spanish National Research Council, Paterna 46980, Spain.ORCID https://orcid.org/0000-0001-9597-311X
Terry GaasterlandBioinformatics & Systems Biology Graduate Program, La Jolla, CA 92093, United States.
Lawrence HunterDepartment of Pediatrics, University of Chicago, Chicago, IL 60637, United States.
Carl KingsfordRay and Stephanie Lane Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA 15213, United States.
Oliver KohlbacherInstitute for Bioinformatics and Medical Informatics, University of Tübingen, Tübingen 72076, Germany.ORCID https://orcid.org/0000-0003-1739-4598
Thomas LengauerMax Planck Institute for Informatics and Saarland Informatics Campus, Saarbrücken 66123, Germany.ORCID https://orcid.org/0000-0003-3801-2640
Scott MarkelDassault Systèmes BIOVIA, San Diego, CA 92121, United States.
Yves MoreauElektrotechniek ESAT-STADIUS, University of Leuven, Leuven 3000, Belgium.ORCID https://orcid.org/0000-0002-4647-6560
William S NobleDepartment of Genome Sciences, University of Washington, Seattle, WA 98195, United States.ORCID https://orcid.org/0000-0001-7283-4715
Christine OrengoDepartment of Structural and Molecular Biology, University College London, London WC1E 6BT, United Kingdom.
B F Francis OuelletteMontreal, QC H2T 2W5, Canada.
Laxmi ParidaIBM T J Watson Research, Yorktown Heights, NY 10598, United States.ORCID https://orcid.org/0000-0002-7872-5074
Natasa PrzuljComputational Biology Department, Mohamed bin Zayed University of Artificial Intelligence, Abu Dhabi SE45 05, United Arab Emirates.ORCID https://orcid.org/0000-0002-1290-853X
Teresa M PrzytyckaComputational Biology Branch, Division of Intramural Research, National Library of Medicine, Bethesda, MD 20894, United States.
Shoba RanganathanDepartment of Chemistry and Biomolecular Sciences, Macquarie University, Sydney, NSW 2109, Australia.ORCID https://orcid.org/0000-0002-8290-813X
Russell SchwartzRay and Stephanie Lane Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA 15213, United States.ORCID https://orcid.org/0000-0002-4970-2252
Alfonso ValenciaBarcelona Supercomputing Center, Barcelona 08034, Spain.
Tandy WarnowSchool of Computing and Data Science, University of Illinois Urbana-Champaign, Urbana, IL 61801, United States.ORCID https://orcid.org/0000-0001-7717-3514

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Summary: Modern biological research critically depends on public databases. The introduction and propagation of errors within and across databases can lead to wasted resources as scientists are led astray by bad data or have to conduct expensive validation experiments. The emergence of generative artificial intelligence systems threatens to compound this problem owing to the ease with which massive volumes of synthetic data can be generated. We provide an overview of several key issues that occur within the biological data ecosystem and make several recommendations aimed at reducing data errors and their propagation. We specifically highlight the critical importance of improved educational programs aimed at biologists and life scientists that emphasize best practices in data engineering. We also argue for increased theoretical and empirical research on data provenance, error propagation, and on understanding the impact of errors on analytic pipelines. Furthermore, we recommend enhanced funding for the stewardship and maintenance of public biological databases. Availability and implementation: Not applicable.

Identifiers

PMID40177265
PMCPMC11964588

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.