ArticleInfection and drug resistance2025
Role of Antimicrobial Stewardship in Modulating Antibiotic Use and Mitigating Bacterial Resistance in a Tertiary Care Setting During COVID-19.
Article in Infection and drug resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Association of a Hospital-Wide Integrated Stewardship Intervention with Hospital-Acquired Multidrug-Resistant Organism Infection Incidence Density: A Large-Scale Interrupted Time-Series Study.Antibiotics (Basel, Switzerland) · 2026Article
- Impact of a Pharmacist-Led Grid-Based Stewardship Program on the Association Between Antimicrobial Use and Resistance: A 7.5-Year Interrupted Time-Series Analysis in a Chinese Tertiary Hospital.Infection and drug resistance · 2026Article
- Impact of an Antimicrobial Stewardship Program on Pre-Therapy Pathogen Detection Specimen Submission, Antimicrobial Use, and Resistant Pathogens: An Interrupted Time Series Analysis.Infection and drug resistance · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Despite the widespread adoption of antimicrobial stewardship (AMS) programs, their effectiveness varies because of differing regional policies and socioeconomic factors. This study aimed to assess the impact of AMS at a Chinese tertiary care hospital on inpatient antimicrobial use and bacterial resistance during the COVID-19 outbreak. Methods: An interrupted time-series regression analysis was conducted to compare inpatient antimicrobial use between pre- and post-intervention periods. The Chi-squared test and linear regression analysis were used to compare bacterial resistance and illustrate temporal trends in bacterial resistance, respectively. Results: Following the AMS strategy implementation, we observed a significant decrease in antimicrobial consumption at unrestricted (β2 = -6.38, P = 0.004), restricted (β2 = -17.81, P < 0.001), and special levels (β2 = -2.32, P < 0.001). Despite a reduction in the use of third-generation cephalosporins and macrolides (β2 = -6.85, P < 0.001; β2 = -2.82, P < 0.001), an increase in the trend of use was observed post-intervention (β3 = 0.15, P < 0.001; β3 = 0.04, P = 0.001). Methicillin resistance in Conclusion: An AMS program in a Chinese tertiary facilitated effective management of antimicrobial use and reduction of bacterial resistance during the COVID-19 pandemic, in the context of combined infection prevention and control measures. The findings provide useful insights for the implementation of antimicrobial stewardship in future public health crises.
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