ReviewEcancermedicalscience2025
Challenges of osteosarcoma care in Africa: a scoping review of the burden, management and outcome.
Review in Ecancermedicalscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Emerging Nanocarrier Strategies for Optimized Drug Delivery in the Treatment of Primary Bone Cancer.Oncology research · 2026Review
- Age Matters: A Systematic Review of Limb-Salvage Surgery Outcomes in Pediatric Versus Adult Osteosarcoma.Cureus · 2025Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteosarcoma has the highest incidence among individuals of African descent, with growing evidence suggesting ethnic and racial genetic underpinning. Hence, it presents a grave public health challenge in Africa given the widening inequities in access to cancer care. This scoping review addresses the critical gap in the availability of locally relevant data on the magnitude of the burden and challenges relating to the management and outcome of African centres. This study included 1,374 patients from eighteen studies. 81% presented with locally advanced or metastatic disease. While surgical treatment for osteosarcoma is shifting toward limb salvage on a global scale, amputation remains preponderant in Africa as only 53% underwent limb salvage operations. The pooled 5-year overall survival was 49.1%. Late presentation, workforce and infrastructural shortage, cultural beliefs, patronage of unorthodox medicine practitioners and high healthcare costs were the barriers driving poor outcomes in African centres. Strategies to improve outcomes should focus on addressing these barriers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.