ArticleRoyal Society open science2025
Costs and constraints of cellular immune activity during development in an arboreal primate.
Article in Royal Society open science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Minimal Evidence of Inflammaging in Naturalistic Chimpanzee Populations.American journal of biological anthropology · 2026Article
- Neopterin as a Tool for Primate Ecoimmunology: Current Knowledge, Practical Application, and New Directions From Captivity to the Wild.American journal of primatology · 2025Review
- Costs and constraints of cellular immune activity during development in an arboreal primate.Royal Society open science · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evolutionary life history theory predicts that, during development, investment in immunity must be balanced with the demands of growth. How, and at what time scales, this balance is negotiated is unclear. In this study, we examined the potential energetic costs and limitations to cellular immune activity during development, its trade-offs with growth, related sickness behaviour and the role of hypothalamic-pituitary-adrenal (HPA) axis activity in these relationships. We combined biomarker and socio-environmental data on wild juvenile blue monkeys collected over eight months. Rather than detract from energy balance (C-peptide) and growth of lean body mass (creatinine by specific gravity residuals), cellular immune activity (neopterin) increased with energy balance and lean body mass at monthly time scales, suggesting an energetic constraint on cellular immunity. At shorter time scales, higher neopterin diminished subsequent growth. Energetic constraints on immune activity were weakly regulated by HPA activity during low energy states. Our results suggest that cellular immune activity is both costly and limited by physical condition in wild developing primates.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.