Evidence map›Paper›PMID 40177100›Full record

ArticleRoyal Society open science2025

Phenothiazine-linked glutamic acid dendrons: an easy access and a new class of SARS-CoV-2 main protease inhibitors.

Sameer Singh, Aditi Gangopadhyay, Sriram D, Manab Chakravarty

Abstract read
In one paragraph

Article in Royal Society open science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sameer SinghDepartment of Chemistry, Birla Institute of Technology & Science Pilani - Hyderabad Campus, Hyderabad, Telangana, India.
Aditi GangopadhyayDepartment of Chemical Technology, University of Calcutta, Kolkata, West Bengal, India.
Sriram DDepartment of Pharmacy, Birla Institute of Technology & Science Pilani, Hyderabad, Telangana, India.
Manab ChakravartyDepartment of Chemistry, Birla Institute of Technology & Science Pilani - Hyderabad Campus, Hyderabad, Telangana, India.ORCID https://orcid.org/0000-0001-8604-7886

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this report, a structurally unique phenothiazine (PTZ) core is linked with glutamic acid-based dendrons through a solid-phase peptide synthesis approach to access a variety of PTZ-linked dendrons conveniently. Inferior cytotoxicity of anionic surface-linked second-generation glutamic acid-based dendrons would be more desirable for various applications than respective lysine-based dendrons. Solid-phase synthesis of PTZ-linked glutamic acid-based dendrons would be a novel approach to access this class of molecules. These newly synthesized dendrons were screened as an inhibitor against the main protease (M

Indexed as

dendronsglutamic acidphenothiazine-linkedSARS-CoV2

Identifiers

PMID40177100
PMCPMC11961260

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.