Evidence map›Paper›PMID 40176879›Full record

ArticleActa biochimica Polonica2025

Prognostic role of IL-34 in sepsis and sepsis-induced acute lung injury: preliminary results and future directions.

Run Cai, Jianke Ren, Chenwei Zhou, Yuxin Liu, Jianlei Tang, Weiyan Cui, Yongmin Yan, Sheliang Xue, Yanjuan Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biochimica Polonica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Run CaiDepartment of Respiratory and Critical Care Medicine, Wujin Hospital Affiliated with Jiangsu University, Changzhou, China.
Jianke RenNational Health Commission Key Lab of Reproduction Regulation, Shanghai Engineering Research Center of Reproductive Health Drug and Devices, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai, China.
Chenwei ZhouDepartment of Respiratory and Critical Care Medicine, Wujin Hospital Affiliated with Jiangsu University, Changzhou, China.
Yuxin LiuDepartment of Respiratory and Critical Care, Changzhou No. 7 People's Hospital, Changzhou, China.
Jianlei TangIntensive Care Unit, Wujin Hospital Affiliated with Jiangsu University, Changzhou, China.
Weiyan CuiIntensive Care Unit, Wujin Hospital Affiliated with Jiangsu University, Changzhou, China.
Yongmin YanCentral Laboratory, Wujin Hospital Affiliated with Jiangsu University, Changzhou, China.
Sheliang XueDepartment of Cardiology, Wujin Hospital Affiliated with Jiangsu University, Changzhou, China.
Yanjuan ZhouDepartment of Respiratory and Critical Care Medicine, Wujin Hospital Affiliated with Jiangsu University, Changzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study aimed to evaluate the potential of interleukin-34 (IL-34) as a novel biomarker for predicting mortality in sepsis patients, with a specific focus on those with sepsis-induced acute lung injury (ALI). Methods: This prospective cohort study enrolled 115 sepsis patients admitted to the intensive care unit (ICU). The patients were divided into survival and non-survival groups, as well as ALI and non-ALI subgroups. Serum levels of IL-34, in conjunction with other established biomarkers such as interleukin-6 (IL-6), C-reactive protein (CRP), and lactate, were measured and analyzed. Statistical analyses, including receiver operating characteristic (ROC) curves, Kaplan-Meier survival curves and Cox regression models, were used to determine the prognostic significance of IL-34. Results: Serum IL-34 levels were significantly elevated in sepsis patients compared to healthy controls, and they were also higher in non-survival group compared to survival group ( Conclusion: IL-34 shows promise as an independent prognostic factor in sepsis patients and may enhance risk stratification, especially in those with sepsis-induced ALI.

Indexed as

Acute Lung InjuryInterleukinsSepsisAdultAgedBiomarkersC-Reactive ProteinFemaleHumansIntensive Care UnitsInterleukin-6Kaplan-Meier EstimateMaleMiddle AgedPrognosisProportional Hazards ModelsBiomarkersC-Reactive ProteinIL34 protein, humanInterleukin-6InterleukinsALIIL-34prognosisrisk stratificationsepsis

Identifiers

PMID40176879
PMCPMC11963693

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.