Trial reportJournal of cosmetic dermatology2025
In Vitro and In Vivo Evaluation of an Emollient-Rich Moisturizer Developed to Address Three Critical Elements of Natural Moisturization.
Trial report in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Branched Hyaluronic Acid for Reduced Viscosity and Enhanced Moisturization.Materials (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
backgroundA new, emollient-rich moisturizing cream has been developed to support three critical elements of natural skin moisturization-hyaluronic acid, natural moisturizing factors, and lipids.
aimsThe aim of this study was to evaluate in vitro biomarkers associated with skin hydration and barrier support, followed by in vivo clinical hydration assessment and tolerability.
methodsUsing an in vitro epidermal skin model, tissues were treated with the study moisturizer or control (saline) for 24 h. Genes associated with hydration and barrier support were analyzed: claudin 4 (CLD4), aquaporin 3 (AQP3), hyaluronic acid synthase 2 (HAS2), and hyaluronidase 1 (HYAL1). The clinical study evaluated twice-daily use of the study moisturizer in subjects with moderate-to-severe dry skin. Subject satisfaction and skin hydration measurements were captured at baseline, 2, 4, and 8 weeks.
resultsIncreased expression of CLD4, AQP3, and HAS2 and reduced activity of HYAL1 were demonstrated after 24 h. In subjects applying the study moisturizer, significant mean percent improvements from baseline in skin hydration occurred at Weeks 2 (41%; p < 0.0001), 4 (38%; p < 0.0001), and 8 (116%; p < 0.0001). Ninety-six percent of subjects reported their skin felt hydrated after 8 weeks.
conclusionsAn emollient-rich moisturizing cream developed to support three critical elements of natural skin moisturization increased the expression of biomarkers associated with skin barrier support and hydration, and reduced the expression of HA-degrading enzymes. Early, significant increases in skin hydration were observed.
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