ArticleHaematologica2025
Long-term kidney complications in childhood leukemia survivors: a study from the Childhood and Adolescent Leukemia (LEA) project.
Article in Haematologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01756599 (Multi-centre Prospective Cohort of Childhood Leukaemia), which is not on this map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Multi-centre Prospective Cohort of Childhood Leukaemia: Determinants of Health and Quality of Life of the Patients After Treatment for an Acute Leukaemia During Childhood or Adolescence - LEA
Who cites it
1 citing paper in PubMed.
- Incidence of and risk factors for chronic kidney disease in childhood cancer survivors.Pediatric nephrology (Berlin, Germany) · 2026Article
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21 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Acute leukemias represent the first cause of cancer in children. Their prognosis has improved significantly due to remarkable advances in therapeutic management, despite the risk of long-term consequences, especially for patients who underwent allogenic hematopoietic stem cell transplantation (aHSCT). Through the Leukemia in Children and Adolescents (LEA) long-term follow-up cohort (clinicaltrials gov. Identifier: NCT01756599), we conducted a French national multicenter prospective study on the occurrence and risk factors of chronic kidney disease (CKD), differentiating glomerular and tubular dysfunctions, corresponding to the NephroLEA project. Among the 1,676 patients included, the median age at evaluation was 15.8 (interquartile range [IQR], 11.3-20.5) years, with a median follow-up of 9.2 (IQR, 5.8-13.9) years. aHSCT was performed on 343 (20.6%) patients, half of whom have undergone the procedure after achieving second or greater remission. A higher percentage of children among transplanted patients had diastolic and systolic blood pressure above the 95th, with 13.7% versus 5.2% (P=3x10-3) and 15% versus 6.5% (P=9x10-2), respectively. A total of 187 patients (11.1%) had a mild CKD (i.e., eGFR between 75 and 90 mL/min/1.73 m2), while 3% (N=50) exhibited mild to severe CKD (eGFR <75 mL/min/1.73 m2). Notably, no patient reached kidney failure. Twenty-one patients (1.3%) had decreased glomerular filtration rate associated with tubular impairment. The principal risk factors for developing CKD were aHSCT and leukemia relapse. In conclusion, CKD represents a long-term risk for patients who relapsed and/or underwent aHSCT. These patients could benefit from nephroprotection advice to further improve their long-term outcomes, which is becoming a public health issue.
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