Evidence map›Paper›PMID 40176749›Full record

Observational studyEuropean journal of pain (London, England)2025

Exploring the Spectrum of Temporal Summation and Conditioned Pain Modulation Responses in Pain-Free Individuals Using a Tonic Heat Pain and Cold Pressor Test Paradigms.

M Vincenot, G Léonard, C Cloutier-Langevin, M Bordeleau, L Gendron, F Camirand Lemyre, S Marchand

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in European journal of pain (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03376867 (Reference Values of Diffuse Noxious Inhibitory Controls), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03376867 unknown statusnot on this map

Reference Values of Diffuse Noxious Inhibitory Controls (DNIC) Intensity in a Healthy Adult Population and Develop a Clinical Test to Evaluate DNIC

TypeobservationalSponsorUniversité de SherbrookeRan2017 to 2024Enrolled468ConditionsChronic PainArmsConditioned pain modulation
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

M VincenotResearch Center on Aging, CIUSSS de L'estrie-CHUS, Université de Sherbrooke, Sherbrooke, Quebec, Canada.ORCID https://orcid.org/0000-0001-7762-1743
G LéonardResearch Center on Aging, CIUSSS de L'estrie-CHUS, Université de Sherbrooke, Sherbrooke, Quebec, Canada.ORCID https://orcid.org/0000-0002-3625-3072
C Cloutier-LangevinDepartment of Mathematics, Faculty of Sciences, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
M BordeleauResearch Center on Aging, CIUSSS de L'estrie-CHUS, Université de Sherbrooke, Sherbrooke, Quebec, Canada.ORCID https://orcid.org/0000-0002-5908-9068
L GendronDepartment of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Quebec, Canada.ORCID https://orcid.org/0000-0002-2058-8863
F Camirand LemyreDepartment of Mathematics, Faculty of Sciences, Université de Sherbrooke, Sherbrooke, Quebec, Canada.ORCID https://orcid.org/0000-0003-3277-2729
S MarchandDepartment of Surgery, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Quebec, Canada.

Funding

Canadian Institutes of Health Research (CIHR 031422Fonds de recherche du Québec-Santé (FRQS)Natural Sciences and Engineering Research Council of Canada (NSERC) 323767Patient-Oriented Research (SPOR)
6 · The paper itself

Abstract

backgroundTemporal summation (TS) and conditioned pain modulation (CPM) are impaired in many chronic pain individuals, although typical TS and CPM responses remain unclear. Providing a quantile distribution of TS and CPM values could help determine whether TS and CPM responses fall outside the usual ranges, thereby informing pain management strategies. The objective of this study was to provide a response distribution for these mechanisms in a large, pain-free cohort.

methodsPain-free participants (n = 347) were evaluated. TS was interpreted as the change in pain perception scores during a constant heat pain stimulus. CPM was assessed by the difference in pain perception scores induced by a tonic heat pain stimulus and a mechanical pain threshold, before and after a cold pressor test (CPT). Quantile regression was performed to identify the 5th to 95th percentiles, with a specific focus on the 75th, 90th and 95th percentiles and their confidence intervals, while considering age and sex.

resultsAnalyses revealed a particularly large range of TS and CPM responses, spanning from strong inhibition in CPM and strong summation in TS to moderate or even null effects. Notably, some responses deviated from the expected patterns, with certain individuals exhibiting hyperalgesic CPM effects and others displaying hypoalgesic TS responses. The highest percentiles of the TS distribution were influenced by age and gender, while CPM scores remained unchanged.

conclusionThe results of this study provide an overview of the possible spectra of responses for TS and CPM, potentially paving the way for their incorporation into pain management strategies. SIGNIFICANCE STATEMENT: This study examines the spectrum and provides a distribution for TS and CPM values to better identify what may constitute a deficit in these mechanisms and enhance their clinical interpretation.

trial registrationclinicaltrial.gov identifier: NCT03376867.

Indexed as

Conditioning, PsychologicalPain PerceptionPain ThresholdAdultAgedCold TemperatureFemaleHot TemperatureHumansHyperalgesiaMaleMiddle AgedPain MeasurementYoung Adult

Identifiers

PMID40176749
PMCPMC11966350

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.