Evidence map›Paper›PMID 40176683›Full record

Observational studyCancer reports (Hoboken, N.J.)2025

A Single Arm Pilot Observational Study to Evaluate the Safety and Feasibility of a Pre-Operative Very Low Calorie Diet in Severely Obese Patients With Endometrial Cancer.

Chloe Ayres, Hanna Burbidge, Jayna Garratt, Ganendra Raj Mohan, Yee Leung, Stephanie Jeffares, Sanela Bilic, Paul A Cohen

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Cancer reports (Hoboken, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chloe AyresWestern Australian Gynaecologic Cancer Service, Department of Obstetrics and Gynaecology, Women and Newborn Health Service, King Edward Memorial Hospital, Subiaco, Western Australia, Australia.
Hanna BurbidgeDepartment of Nutrition and Dietetics, Women and Newborn Health Service, King Edward Memorial Hospital, Subiaco, Western Australia, Australia.
Jayna GarrattWestern Australian Gynaecologic Cancer Service, Department of Obstetrics and Gynaecology, Women and Newborn Health Service, King Edward Memorial Hospital, Subiaco, Western Australia, Australia.
Ganendra Raj MohanWestern Australian Gynaecologic Cancer Service, Department of Obstetrics and Gynaecology, Women and Newborn Health Service, King Edward Memorial Hospital, Subiaco, Western Australia, Australia.
Yee LeungWestern Australian Gynaecologic Cancer Service, Department of Obstetrics and Gynaecology, Women and Newborn Health Service, King Edward Memorial Hospital, Subiaco, Western Australia, Australia.
Stephanie JeffaresDepartment of Gynaecological Oncology, St John of God Subiaco Hospital, Subiaco, Western Australia, Australia.
Sanela BilicDepartment of Gynaecological Oncology, St John of God Subiaco Hospital, Subiaco, Western Australia, Australia.
Paul A CohenWestern Australian Gynaecologic Cancer Service, Department of Obstetrics and Gynaecology, Women and Newborn Health Service, King Edward Memorial Hospital, Subiaco, Western Australia, Australia.ORCID 0000-0002-4860-9232

Funding

The Australian Society of Gynaecological Oncologists
6 · The paper itself

Abstract

backgroundPre-operative very low calorie diets (VLCDs) can achieve rapid and safe weight loss, yet no studies have evaluated VLCDs in the severely obese endometrial cancer population prior to surgery. Our aim was to evaluate the safety and feasibility of a 4-6 week pre-operative nutritional intervention with the Optifast VLCD prior to surgery in patients with clinical stage 1, Grade 1 endometrioid endometrial adenocarcinoma and a body mass index ≥ 35 kg/m

methodsThis was an investigator-initiated single-arm prospective observational study. Co-primary endpoints were safety and feasibility. Secondary endpoints were changes in anthropometric measures, blood pressure, biochemistry, perioperative complications, length of stay and final tumour stage. Tolerability and compliance of the VLCD were assessed by fortnightly questionnaires and urinary ketones.

resultsTwenty-eight patients were enrolled, of which 25 underwent the intervention. 22/25 patients (88%) completed at least 4 weeks of Optifast. Mean (SD) age was 56.4 (6.3) years, and mean body mass index (BMI) was 45.2 (7.1) kg/m

conclusionsA 4-6 week pre-operative VLCD in severely obese clinically low-risk endometrial cancer patients appears safe, feasible and well tolerated.

Indexed as

Caloric RestrictionCarcinoma, EndometrioidEndometrial NeoplasmsObesityObesity, MorbidPreoperative CareAgedBody Mass IndexFeasibility StudiesFemaleHumansMiddle AgedPilot ProjectsProspective StudiesTreatment OutcomeWeight Lossendometrial cancerobesityPrehabilitationsurgeryvery low‐calorie diet (VLCD)

Identifiers

PMID40176683
PMCPMC11965880

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.