Evidence map›Paper›PMID 40176680›Full record

ArticleObstetrics & gynecology science2025

Causal association of cathepsins with female infertility: a bidirectional Mendelian randomization analysis.

Lidan Liu, Ming Liao, Bo Liu, Qianyi Huang, Huimei Wu, Mujun Li

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Article in Obstetrics & gynecology science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Lidan LiuGuangxi Reproductive Medical Center, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Ming LiaoGuangxi Reproductive Medical Center, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Bo LiuGuangxi Reproductive Medical Center, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Qianyi HuangGuangxi Reproductive Medical Center, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Huimei WuGuangxi Reproductive Medical Center, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Mujun LiGuangxi Reproductive Medical Center, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aimed to systematically evaluate potential causal relationships between nine cathepsins and female infertility using Mendelian randomization (MR).

methods.

methodsA bidirectional MR analysis was conducted utilizing single nucleotide polymorphisms as instrumental variables to investigate the potential causal effects between nine cathepsins and female infertility. Genetic data on female infertility were sourced from the FinnGen study, and cathepsin-related data were obtained from genome-wide association studies datasets of European ancestry.

resultsElevated levels of cathepsin E were significantly and inversely associated with the risk of female infertility, suggesting a potential protective role. This finding was further supported by multivariable MR analysis. However, no significant associations were observed between the other eight cathepsins and female infertility.

conclusionThis study represents the first systematic MR analysis to identify a potential protective effect of cathepsin E on female infertility.

Indexed as

Cathepsin EFemale infertilityMendelian randomization

Identifiers

PMID40176680
PMCPMC12104616

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