VCAM1-mediated regulation of dopaminergic neuron function in Parkinson's disease.

Mihee Oh, Sunha Lee, Eunhye Kim, Yewon Jang, Baek-Soo Han

Abstract read

In one paragraph

Article in BMB reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Pro-Inflammatory Protein PSCA Is Upregulated in Neurological Diseases and Targets β2-Subunit-Containing nAChRs.Biomolecules · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mihee OhBiodefense Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea.

Sunha LeeBiodefense Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141; Department of Functional Genomics, University of Science and Technology (UST), Daejeon 34141, Korea.

Eunhye KimBiodefense Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141; Department of Functional Genomics, University of Science and Technology (UST), Daejeon 34141, Korea.

Yewon JangBiodefense Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea.

Baek-Soo HanBiodefense Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141; Department of Functional Genomics, University of Science and Technology (UST), Daejeon 34141, Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD), the second most common neurodegenerative disorder, is characterized by the degeneration of dopaminergic neurons, striatal dopamine deficiency, and the accumulation of intracellular α-synuclein aggregates. This study employed induced pluripotent stem cell (iPSC) technology to generate dopaminergic neurons from somatic cells of both PD patients and healthy controls. The results demonstrate that patient-derived neurons show elevated expression of vascular cell adhesion molecule 1 (VCAM1), which correlates with altered synaptic plasticity, mitochondrial dysfunction, and impaired Rac1 and FAK2 signaling. These findings suggest that VCAM1 plays a pivotal role in PD pathogenesis, and may serve as a potential therapeutic target. [BMB Reports 2025; 58(5): 217-223].

Indexed as

Dopaminergic NeuronsParkinson DiseaseVascular Cell Adhesion Molecule-1DopamineHumansInduced Pluripotent Stem CellsMitochondriaNeuronal Plasticityrac1 GTP-Binding ProteinSignal TransductionDopaminerac1 GTP-Binding ProteinVascular Cell Adhesion Molecule-1

Identifiers

PMID40176604

PMCPMC12123205

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.