Evidence map›Paper›PMID 40176602›Full record

ArticleBMB reports2025

Tissue-specific lncRNA GATA6-AS1 and its ortholog Moshe as essential regulators of aortic valve development.

Na-Jung Kim, Eun-Hye Moon, Ji Hoon Oh, Hyeon Myeong Kim, Su Haeng Sung, Han-Se Kim, Chae-Yi Kim, Yeo-Jin Im, Jasmin E Turner, Young Jae Lee and 2 more

Abstract read
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In one paragraph

Article in BMB reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Na-Jung KimBK21 Plus and Research Institute for Veterinary Science, Department of Biochemistry, School of Veterinary Medicine, Seoul National University, Seoul 08826; Comparative Medicine Disease Research Center, Seoul National University, Seoul 08826, Korea.
Eun-Hye MoonLee Gil Ya Cancer and Diabetes Institute, Department of Biochemistry, Gachon University, Incheon 21999, Korea.
Ji Hoon OhBK21 Plus and Research Institute for Veterinary Science, Department of Biochemistry, School of Veterinary Medicine, Seoul National University, Seoul 08826; Comparative Medicine Disease Research Center, Seoul National University, Seoul 08826, Korea.
Hyeon Myeong KimDepartment of Pathology, College of Medicine, Kyung Hee University, Seoul 02447, Korea.
Su Haeng SungDepartment of Pathology, College of Medicine, Kyung Hee University, Seoul 02447, Korea.
Han-Se KimBK21 Plus and Research Institute for Veterinary Science, Department of Biochemistry, School of Veterinary Medicine, Seoul National University, Seoul 08826; Comparative Medicine Disease Research Center, Seoul National University, Seoul 08826, Korea.
Chae-Yi KimBK21 Plus and Research Institute for Veterinary Science, Department of Biochemistry, School of Veterinary Medicine, Seoul National University, Seoul 08826; Comparative Medicine Disease Research Center, Seoul National University, Seoul 08826, Korea.
Yeo-Jin ImBK21 Plus and Research Institute for Veterinary Science, Department of Biochemistry, School of Veterinary Medicine, Seoul National University, Seoul 08826; Comparative Medicine Disease Research Center, Seoul National University, Seoul 08826, Korea.
Jasmin E TurnerBiosciences Institute, Newcastle University, Newcastle upon Tyne NE14EP, United Kingdom.
Young Jae LeeLee Gil Ya Cancer and Diabetes Institute, Department of Biochemistry, Gachon University, Incheon 21999, Korea.
Yong Jun KimDepartment of Pathology, College of Medicine, Kyung Hee University, Seoul 02447, Korea.
Je-Yoel ChoBK21 Plus and Research Institute for Veterinary Science, Department of Biochemistry, School of Veterinary Medicine, Seoul National University, Seoul 08826; Comparative Medicine Disease Research Center, Seoul National University, Seoul 08826, Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long noncoding RNAs (lncRNAs) are integral to epigenetic regulation during cardiogenesis; however, their role in aortic valve disease is not well characterized. Investigating lncRNAs present in the human embryonic heart and pinpointing their specific isoforms presents notable challenges due to both technical and ethical limitations. In our research, we identified GATA6- AS1 as a lncRNA predominantly found in the heart by analyzing publicly accessible RNA sequencing data derived from human embryonic tissues. Employing in vitro models along with CS17 embryonic heart tissue, we determined that isoforms 202 and 208 of GATA6-AS1 are uniquely expressed in cardiac neural crest lineage cells throughout the development of the aortic valve. We also identified Moshe, the murine ortholog of GATA6-AS1, whose expression occurs during aortic valve formation in mice. Notably, depletion of Moshe results in the development of bicuspid aortic valves (BAV), accompanied by a significant downregulation of genes associated with BAV, particularly those related to the Notch and TGF-β signaling pathways. These findings highlight the critical role of GATA6-AS1 in aortic valve development through the study of its mouse ortholog Moshe. They also suggest that lncRNAs, still underexplored in congenital heart disease research, may hold significant implications for BAV pathogenesis and potential therapeutic strategies. [BMB Reports 2025; 58(4): 175-182].

Indexed as

Aortic ValveRNA, Long NoncodingAnimalsBicuspid Aortic Valve DiseaseGATA6 Transcription FactorGene Expression Regulation, DevelopmentalHeart Valve DiseasesHumansMiceSignal TransductionGATA6 Transcription FactorRNA, Long Noncoding

Identifiers

PMID40176602
PMCPMC12041926

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.