Evidence map›Paper›PMID 40176499›Full record

ArticleAddiction (Abingdon, England)2025

Longitudinal patterns of e-cigarette use initiation and progression to frequent vaping from mid-to-late adolescence to young adulthood.

Junhan Cho, Alyssa F Harlow, Adam M Leventhal, Mary Ann Pentz, Dayoung Bae, Dae-Hee Han, Rob McConnell, Sandrah P Eckel, Jessica L Barrington-Trimis

Abstract read
In one paragraph

Article in Addiction (Abingdon, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Junhan ChoDepartment of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0002-6617-1625
Alyssa F HarlowDepartment of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0001-6744-6988
Adam M LeventhalDepartment of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0002-1217-525X
Mary Ann PentzDepartment of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0001-6668-8862
Dayoung BaeDepartment of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.ORCID https://orcid.org/0009-0006-2623-7454
Dae-Hee HanDepartment of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0002-2929-5928
Rob McConnellDepartment of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0001-5243-6410
Sandrah P EckelDepartment of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0001-6050-7880
Jessica L Barrington-TrimisDepartment of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0002-3331-0326

Funding

USC Tobacco Center of Regulatory ScienceU54CA180905 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Adam Matthew Leventhal · 2018 to 2026
$39.0M
Vaping Nicotine and Cannabis Across Adolescence and Young AdulthoodR01CA229617 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BARRINGTON-TRIMIS, JESSICA LOUISE, LEVENTHAL, ADAM MATTHEW · 2019 to 2024
$4.3M
Tobacco Use Treatment Research for Vulnerable PopulationsK24DA048160 · NIDA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Adam Matthew Leventhal · 2019 to 2026
$1.4M
The Tobacco and Cannabis Retail Environment, Neighborhood Disadvantage, and Adolescent VapingK01DA058084 · NIDA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Alyssa Fitzpatrick Harlow · 2023 to 2026
$752k
Vaping and Smoking Cessation in Intensive Longitudinal National DataR21DA058343 · NIDA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHO, JUNHAN, LEVENTHAL, ADAM MATTHEW · 2023 to 2024
$454k
NCI NIH HHS R01 CA229617NCI NIH HHS U54 CA180905NCI NIH HHS U54CA180905NIDA NIH HHS K01 DA058084NIDA NIH HHS K01DA058084NIDA NIH HHS K24 DA048160NIDA NIH HHS K24DA048160NIDA NIH HHS R21 DA058343NIDA NIH HHS R21DA058343NIH HHS R01CA229617
6 · The paper itself

Abstract

aimsThis exploratory study aimed to describe longitudinal patterns of e-cigarette use initiation and progression to frequent use across mid-to-late adolescence and young adulthood and determine risk factors for and consequences of these initiation patterns.

designUsing 12 waves of a prospective cohort data across 2014-2023, we identified latent classes with distinct patterns of timing of e-cigarette use initiation and frequent use progression (20 + days/month). We then estimated: (1) associations of baseline risk factors with membership in latent classes and (2) associations of latent classes with e-cigarette/other substance use frequency and e-cigarette dependence at a subsequent 1-year follow-up.

settingSouthern California, United States.

participantsBaseline e-cigarette never users [n = 2291; mean age (standard deviation) = 15.0 (0.4) years; 55.1% female; 44.6% Hispanic]. MEASUREMENTS: Repeated self-reported e-cigarette use initiation and past-30-day frequency, other substance use and e-cigarette dependence.

findingsFour distinct groups were identified: (1) early high school/gradual progression (13.9%); (2) late high school/gradual progression (4.3%); (3) young adulthood/quick progression (21.3%); and (4) low initiation risk/no progression (60.5%). In addition to two high school initiator groups with gradual progression to frequent vaping over 3 years, we identified the young adulthood/quick progression group who initiated e-cigarette use after high school and progressed to frequent use within 1.2 years. Late initiators who progressed quickly reported the highest prevalence of JUUL use as their first device (34.2%) and the highest levels of vaping frequency and e-cigarette dependence at the final assessment, compared with the other groups.

conclusionsIn the United States, there appear to be four distinct classes of developmental patterns of e-cigarette use initiation and progression to frequent use during mid-to-late adolescence and young adulthood, including a newly identified group characterized by late use initiation (post secondary school) and rapid progression (1.2 years) to frequent use. Rapid progression from late initiation to frequent use may be influenced by the widespread availability and usage of JUUL among US youth in 2018-2019.

Indexed as

Electronic Nicotine Delivery SystemsVapingAdolescentCaliforniaDisease ProgressionFemaleHumansLongitudinal StudiesMaleProspective StudiesRisk FactorsSubstance-Related DisordersYoung Adulte‐cigarette dependencee‐cigarette use initiatione‐cigarette use progressionJUULsurvival analysisyouth

Identifiers

PMID40176499
PMCPMC12771528

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.