Evidence map›Paper›PMID 40176435›Full record

ArticlePsychological medicine2025

Do psychotic symptoms predict future psychotic disorders in adolescent psychiatry inpatients? A 17-year cohort study.

Valentina Kieseppä, Ulla Lång, Colm Healy, Kirstie O'Hare, Covadonga M Díaz-Caneja, Sinan Gülöksüz, Bart P F Rutten, Mary Cannon, Anu-Helmi Halt, Pirkko Riipinen and 1 more

Abstract read
In one paragraph

Article in Psychological medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Valentina KieseppäCentre for Clinical Brain Sciences, Division of Psychiatry, University of Edinburgh, Edinburgh, UK.ORCID 0000-0001-5366-7448
Ulla LångCentre for Clinical Brain Sciences, Division of Psychiatry, University of Edinburgh, Edinburgh, UK.
Colm HealyCentre for Clinical Brain Sciences, Division of Psychiatry, University of Edinburgh, Edinburgh, UK.
Kirstie O'HareCentre for Clinical Brain Sciences, Division of Psychiatry, University of Edinburgh, Edinburgh, UK.
Covadonga M Díaz-CanejaDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio MaraÑón (IiSGM), CIBERSAM, ISCIII, School of Medicine, Universidad Complutense, Madrid, Spain.
Sinan GülöksüzDepartment of Psychiatry and Neuropsychology, Mental Health and Neuroscience Research Institute, Maastricht University, Faculty of Health, Medicine and Life Sciences, Maastricht, the Netherlands.
Bart P F RuttenDepartment of Psychiatry and Neuropsychology, Mental Health and Neuroscience Research Institute, Maastricht University, Faculty of Health, Medicine and Life Sciences, Maastricht, the Netherlands.
Mary CannonDepartment of Psychiatry, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
Anu-Helmi HaltResearch Unit of Clinical Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland.
Pirkko RiipinenResearch Unit of Clinical Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland.
Ian KelleherCentre for Clinical Brain Sciences, Division of Psychiatry, University of Edinburgh, Edinburgh, UK.

Funding

Health Research Board CDA 2021-0005Instituto de Salud Carlos III PI17/00481, PI20/00721, PI23/00625, JR19/00024
6 · The paper itself

Abstract

backgroundIndividuals with a psychiatric inpatient admission in adolescence have a high risk of schizophrenia-spectrum disorders (SSDs) when followed to adulthood. Whether psychotic symptoms predict subsequent SSDs in inpatient cohorts, however, is an important unanswered question.

methodsThe sample consisted of adolescents (aged 13-17) admitted to psychiatric inpatient care (Oulu, Finland) from April 2001 to March 2006. Psychotic symptoms were assessed with the Schedule for Affective Disorders and Schizophrenia. Specialized health care use and diagnoses were followed up in national health care registers until June 2023. Cox regression was used to predict SSDs by the presence of baseline psychotic symptoms.

resultsOf 404 adolescent inpatients admitted with non-psychotic mental disorders, 28% (

conclusionsThere was a high risk of subsequent SSDs among adolescent psychiatry inpatients when followed over time. SSDs were not predicted by subthreshold psychotic symptoms. Full-threshold psychotic symptoms were associated with an increased risk of subsequent SSDs, though with low sensitivity.

Indexed as

InpatientsPsychotic DisordersSchizophreniaAdolescentAdolescent PsychiatryCohort StudiesFemaleFinlandFollow-Up StudiesHospitalizationHospitals, PsychiatricHumansMalechild and adolescent mental health servicesinpatient treatmentpsychosispsychotic symptomstransition

Identifiers

PMID40176435
PMCPMC12094655

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.