Evidence map›Paper›PMID 40176419›Full record

ArticleACS chemical biology2025

Engineering the Specificity of Acetyl-CoA Synthetase for Diverse Acyl-CoA Thioester Generation.

Jared R Cossin, Thaddeus Q Paulsel, Kim Castelli, Breck Wcisel, Alexandra A Malico, Gavin J Williams

Abstract read
In one paragraph

Article in ACS chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Engineering an Acyl-CoA Ligase With Enhanced Activity Toward Synthetic CoA Alternatives.Chembiochem : a European journal of chemical biology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jared R CossinNorth Carolina State University, Raleigh, North Carolina 27695, United States.
Thaddeus Q PaulselNorth Carolina State University, Raleigh, North Carolina 27695, United States.
Kim CastelliNorth Carolina State University, Raleigh, North Carolina 27695, United States.
Breck WciselNorth Carolina State University, Raleigh, North Carolina 27695, United States.ORCID 0009-0007-9848-3694
Alexandra A MalicoNorth Carolina State University, Raleigh, North Carolina 27695, United States.
Gavin J WilliamsNorth Carolina State University, Raleigh, North Carolina 27695, United States.ORCID 0000-0003-2172-9063

Funding

Synthetic Biology Approach to Regioselectively Modified PolyketidesR01GM104258 · NIGMS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI WILLIAMS, GAVIN J · 2013 to 2017
$1.4M
NIGMS NIH HHS R01 GM104258
6 · The paper itself

Abstract

CoA thioesters are valuable intermediates in numerous biosynthetic routes and metabolic processes. However, diversifying these compounds and their corresponding downstream products hinges on broadening the promiscuity of CoA ligases that produce them or using additional enzymes to functionalize them. Here, the inherent promiscuity of an acyl-CoA ligase from

Indexed as

Acetate-CoA LigaseAcyl Coenzyme AProtein EngineeringPolyketide SynthasesPseudomonasSubstrate SpecificityAcetate-CoA LigaseAcyl Coenzyme APolyketide Synthases

Identifiers

PMID40176419
PMCPMC12483075

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.