ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Altered Brain-Behavior Association During Resting State is a Potential Psychosis Risk Marker.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Altered Brain-Behavior Association During Resting State is a Potential Psychosis Risk Marker.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
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Authors and funding
22 authors.
Funding
Abstract
Alterations in cognitive and neuroimaging measures in psychosis may reflect altered brain-behavior interactions patterns accompanying the symptomatic manifestation of the disease. Using graph connectivity-based approaches, we tested the brain-behavior association between cognitive functioning and functional connectivity at different stages of psychosis. We collected resting-state fMRI of 204 neurotypical controls (NC) in two independent cohorts, 43 patients with chronic psychosis (PSY), and 22 subjects with subthreshold psychotic symptoms (STPS). In NC, we calculated graph connectivity metrics and tested their associations with neuropsychological scores. Replicable associations were tested in PSY and STPS and externally validated in three cohorts of 331, 371, and 232 individuals, respectively. NC showed a positive correlation between the degree centrality of a right prefrontal-cingulum-striatal circuit and total errors on Wisconsin Card Sorting Test. Conversely, PSY and STPS showed negative correlations. External replications confirmed both associations while highlighting the heterogeneity of STPS. Group differences in either centrality or cognition alone were not equally replicable. In four independent cohorts totaling 1,203 participants, we identified a replicable alteration of the brain-behavior association in different stages of psychosis. These results highlight the high replicability of multimodal markers and suggest the opportunity for longitudinal investigations that may test this marker for early risk identification.
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Registered trials
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