Evidence map›Paper›PMID 40176344›Full record

ArticleJournal of cosmetic dermatology2025

Nonsurgical Facial Contouring With a Novel Radiofrequency and Vacuum Device: A Multicenter Retrospective Study With 33 Patients.

Mimi Ehrenraich, Ety Wolff, Suzy Roffe Grumer, Olalla Calvo Lozano, Reyna Vargas, Inna Belenky

Abstract readMulticenter Study
In one paragraph

Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mimi EhrenraichMimi Ehrenraich Aesthetic Clinics, Haifa, Israel.
Ety WolffWolff Aesthetics Center, Herzliya, Israel.
Suzy Roffe GrumerArival Ltd., Tel-Aviv, Israel.
Olalla Calvo LozanoSinclair, London, UK.
Reyna VargasSinclair, London, UK.
Inna BelenkySinclair, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aging process reflects decreased tissue elasticity and a rearrangement of subcutaneous volume, resulting in superficial wrinkles and three-dimensional changes in skin topography. Radiofrequency (RF)-based approaches have become increasingly adopted in recent decades due to their relatively short downtime and significantly reduced risk of adverse effects.

aimsThe aim of this study was to evaluate the safety and efficacy of the V-FC handpiece through a multicenter retrospective study as well as ex vivo and in vivo analyses.

methodsThe V-FC handpiece was used once a week for a treatment course of 3-6 sessions. The clinical evaluation of 33 patients included demographics, BMI, assessment of skin laxity, and rate of improvement. An ex vivo study with porcine tissue assessed the penetration depth of RF, while device performance was evaluated in an in vivo animal histological analysis.

resultsNo significant adverse effects were recorded during the treatment course or at short- and long-term follow-ups (1, 3, and 52 months). The average skin laxity grade baseline was 34% lower at the end of the treatment course, with the average rate of improvement assessed as moderate. The ex vivo minimal and maximal penetration depths were 3.2-11.3 mm (±10%). The in vivo histopathological analysis showed no signs of acute heat injury at any treatment setting, including the maximum RF power. Additionally, staining showed a power-related progressive proliferation of fibroblasts, elastin fibers, and neocollagenesis, which was significantly higher 4 weeks after treatment.

conclusionsThe new RF device demonstrates an effective treatment for facial contouring with a proven short- and long-term high safety profile.

Indexed as

Cosmetic TechniquesRadiofrequency TherapySkin AgingAdultAgedAnimalsElasticityFaceFemaleFollow-Up StudiesHumansMaleMiddle AgedRejuvenationRetrospective StudiesSkinfacial agingfacial contouringradiofrequencyskin laxityvacuum

Identifiers

PMID40176344
PMCPMC11965962

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.