Evidence map›Paper›PMID 40176340›Full record

ArticleJournal of cardiovascular electrophysiology2025

New-Onset Device-Detected Atrial Fibrillation in Patients With Atrial Floating Dipole Implantable Cardioverter-Defibrillators: A Propensity Score-Matched Comparison With Conventional Dual-Chamber Systems.

Gianfranco Mitacchione, Antonio Curnis, Eduardo Celentano, Giovanni Rovaris, Antonella Battista, Massimiliano Marini, Paolo Della Bella, Vincenzo Ezio Santobuono, Mauro Biffi, Luca Tomasi and 20 more

Registry-linked trialAbstract readComparative Study
In one paragraph

Article in Journal of cardiovascular electrophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04869527 (Simplifying Access to Full Early Atrial Diagnostics in Single Chamber ICD Patients Using the DX Lead and Continuous Home Monitoring in Brazil), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04869527 completednot on this map

Simplifying Access to Full Early Atrial Diagnostics in Single Chamber ICD Patients Using the DX Lead and Continuous Home Monitoring in Brazil

Typeobservational_patient_registrySponsorBiotronik SE & Co. KGRan2021 to 2025Enrolled56ConditionsArrhythmias, CardiacArmsBIOTRONIK ICDs with DX Technology
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Gianfranco MitacchioneASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.ORCID 0000-0002-3774-0104
Antonio CurnisASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.
Eduardo CelentanoHumanitas Gavazzeni, Bergamo, Italy.
Giovanni RovarisFondazione IRCCS San Gerardo dei Tintori, Monza, Italy.
Antonella BattistaArcispedale Santa Maria Nuova, Reggio Emilia, Italy.
Massimiliano MariniOspedale Santa Chiara, Trento, Italy.ORCID 0000-0001-9388-3292
Paolo Della BellaOspedale San Raffaele, Milano, Italy.ORCID 0000-0001-8346-1387
Vincenzo Ezio SantobuonoPoliclinico Universitario di Bari, Bari, Italy.
Mauro BiffiPoliclinico Sant'Orsola-Malpighi, Bologna, Italy.ORCID 0000-0003-4590-8584
Luca TomasiAzienda Ospedaliera Universitaria Integrata Verona, Verona, Italy.
Matteo BaroniASST Grande Ospedale Metropolitano Niguarda, Milano, Italy.ORCID 0000-0003-3948-4914
Luca BontempiOspedale di Seriate, Seriate, Italy.
Gerardo NigroUniversità 'Vanvitelli', Ospedale Monaldi, Napoli, Italy.
Emilio Di LorenzoOspedale Monaldi, Napoli, Italy.
Donatella RuggieroOspedale Pio XI, Desio, Italy.
Fabio FranculliOspedale San Giovanni di Dio e Ruggi d'Aragona, Salerno, Italy.
Patrizia PepiOspedale Carlo Poma, Mantova, Italy.
Miguel ViscusiOspedale di Caserta, Caserta, Italy.
Davide SaporitoOspedale Infermi, Rimini, Italy.
Matteo BertiniNuovo Arcispedale S.Anna, Ferrara, Italy.
Gaetano SenatoreOspedale di Ciriè, Ciriè, Italy.
Stefano PedrettiOspedale San Paolo, Milano, Italy.
Domenico PecoraFondazione Poliambulanza Istituto Ospedaliero, Brescia, Italy.
Giovanni Battista ForleoOspedale Sacco, Milano, Italy.
Francesco SolimeneClinica Montevergine, Mercogliano, Italy.
Valerio GiordanoPresidio Ospedaliero San Luca, Vallo della Lucania, Italy.
Riccardo SacchiASST Brianza - Ospedale di Vimercate, Vimercate, Italy.
Daniele GiacopelliBiotronik Italia S.p.a., Cologno Monzese, Italy.ORCID 0000-0003-1584-7944
Alessio GargaroBiotronik Italia S.p.a., Cologno Monzese, Italy.
Fabrizio CaravatiASST dei sette laghi, Ospedale di Circolo, Varese, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDevice-detected subclinical atrial fibrillation (DDAF) is a significant risk factor for major cardiovascular events, especially in implantable cardioverter-defibrillator (ICD) recipients. The DX ICD, which utilizes a single ventricular lead with a floating atrial dipole, has demonstrated superior performance in diagnosing DDAF compared to conventional single-lead ICDs. However, comparisons between DX and dual-chamber (DDD) ICDs for atrial monitoring are limited.

objectiveTo compare the incidence of newly detected DDAF in patients without an indication for atrial pacing who received either a DX or a standard DDD ICD.

methodsRemote transmissions from the Italian Home Monitoring Expert Alliance dataset were analyzed. DDAF incidence for different burden cutoffs ( ≥ 15 min, ≥ 6 h, and ≥ 24 h) was compared between groups using propensity score (PS) matching to adjust for baseline characteristics.

resultsIn a cohort of 1329 patients (527 with DX ICD and 802 with DDD ICD), 30.7% experienced DDAF lasting ≥ 15 min, 22.3% ≥ 6 h, and 14.0% ≥ 24 h during a median follow-up of 4.5 years. DDAF incidence was lower in the DX ICD group for all burden cutoffs (p < 0.0001). However, after PS matching, DDAF rates were similar between groups, with no significant differences (p ≥ 0.36). Multivariate analysis identified age and 1-month right ventricular pacing percentage as predictors of DDAF across all burden cutoffs, with no effect based on device type or programmed basic rate.

conclusionIn patients without atrial pacing indication or history of clinical atrial fibrillation at implantation, the DX ICD demonstrated DDAF detection capabilities comparable to DDD ICDs in a real-world setting.

Indexed as

Atrial FibrillationDefibrillators, ImplantableElectric CountershockHeart RateRemote Sensing TechnologyAction PotentialsAgedAsymptomatic DiseasesFemaleHumansIncidenceItalyMaleMiddle AgedPredictive Value of TestsPropensity Scoredevice‐detected atrial fibrillationDX ICDfloating atrial dipoleimplantable cardioverter‐defibrillatorremote monitoring

Identifiers

PMID40176340
PMCPMC12160691

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.