Evidence map›Paper›PMID 40176335›Full record

ArticleMuscle & nerve2025

A Quantitative Study of Factors Influencing Myasthenia Gravis Telehealth Examination Score.

Marc Garbey, Quentin Lesport, Helen Girma, Gülşen Öztosun, Henry J Kaminski

Abstract read
In one paragraph

Article in Muscle & nerve, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Marc GarbeyDepartment of Surgery, School of Medicine & Health Sciences, George Washington University, Washington, District of Columbia, USA.
Quentin LesportLaboratoire Des Sciences de l'Ingénieur Pour l'Environnement (LaSIE) UMR-CNRS 7356, University of La Rochelle, La Rochelle, France.
Helen GirmaDepartment of Neurology & Rehabilitation, George Washington University, Washington, DC, United States.
Gülşen ÖztosunDepartment of Neurology & Rehabilitation, George Washington University, Washington, DC, United States.ORCID https://orcid.org/0000-0002-1638-9095
Henry J KaminskiDepartment of Neurology & Rehabilitation, George Washington University, Washington, DC, United States.ORCID https://orcid.org/0000-0002-8195-0141

Funding

Rare Disease Network for Myasthenia GravisU54NS115054 · NINDS · GEORGE WASHINGTON UNIVERSITY · PI HENRY J KAMINSKI · 2019 to 2026
$11.9M
National Center for Advancing Translational Sciences (NCATS)National Institute of Neurological Disorders and Stroke (NINDS)National Science FoundationNIH HHSNIH Rare Disease Network MGNet U54NS115054NINDS NIH HHS U54 NS115054NSF I-Corp 838792
6 · The paper itself

Abstract

INTRODUCTION/

aimsThe adoption of telemedicine is generally considered as advantageous for patients and physicians, but there is limited rigorous assessment of examination strengths and limitations. We set out to perform a quantitative assessment of the limitations of a standardized examination of subjects with myasthenia gravis (MG) during video-taped telemedicine sessions.

methodsWe utilized a video bank containing recordings from 51 MG patients who completed two telemedicine-based examinations with neuromuscular experts; each recording included the MG core examination (MG-CE) and the MG activities of daily living (MG-ADL). We then applied artificial intelligence (AI) algorithms from computer vision and speech analysis to natural language processing to generate and assess the reproducibility and inter-rater reliability of the MG-CE and MG-ADL.

resultsWe successfully developed a technology to assess video examinations. While overall MG-CE scores were consistent across examiners, individual metrics showed significant variability, with up to a 25% variation in scoring within the MG-CE's range. Additionally, there was wide variability in adherence to MG-ADL instructions. These variations were attributed to differences in examiner instructions, video recording limitations, and patient disease severity. DISCUSSION: We were able to develop a system of digital analysis of neuromuscular examinations in order to assess variability in individual scoring measures of the MG-ADL and MG-CE. Our approach enabled post hoc quantitative analysis of neuromuscular examinations. Further refinement of this technology could enhance examiner training and reduce variability in clinical trial outcome measures.

Indexed as

Myasthenia GravisTelemedicineActivities of Daily LivingAdultAgedArtificial IntelligenceFemaleHumansMaleMiddle AgedReproducibility of ResultsVideo Recordingartificial intelligencecomputer visionhuman factorneurological examination myasthenia gravistelemedicine

Identifiers

PMID40176335
PMCPMC12140879

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.