Evidence map›Paper›PMID 40176279›Full record

Observational studyMedicine and science in sports and exercise2025

Physical Activity and Sedentary Behavior Differ by Sex during the First 6 Months after Anterior Cruciate Ligament Reconstruction.

Elizabeth Wellsandt, David Werner, Matthew Tao, Kaleb Michaud, Christopher Wichman, Yvonne M Golightly

Abstract readObservational Study
In one paragraph

Observational study in Medicine and science in sports and exercise, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Elizabeth WellsandtUniversity of Nebraska Medical Center, Omaha, NE.ORCID 0000-0003-1983-6812
David Werner
Matthew Tao
Kaleb Michaud
Christopher Wichman
Yvonne M Golightly

Funding

Tracking and Evaluation CoreU54GM115458 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI ZHANG, YING · 2016 to 2025
$42.8M
UNC Core Center for Clinical ResearchP30AR072580 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LEIGH Fleming CALLAHAN, Amanda E Nelson · 2019 to 2026
$6.1M
Is the gut important in multiple joint osteoarthritis? A multimodal investigation in humans and pet dogsR01AR080733 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Duncan Lascelles, Amanda E Nelson · 2022 to 2026
$3.8M
Identifying determinants of rapid structural and/or clinical progression in knee osteoarthritis by quantitative assessment of structural features on radiographsR01AR080742 · NIAMS · UNIVERSITY OF ARIZONA · PI JEFFREY W DURYEA, C KENT KWOH · 2022 to 2026
$3.7M
Knee Arthroplasty Activity Trial (KArAT)R01AR080346 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Elena Losina · 2022 to 2026
$3.6M
Healthy knee aging vs. osteoarthritis in three large diverse cohorts: What is the clinical relevance of structural changes seen on radiographs?R01AR078187 · NIAMS · UNIVERSITY OF ARIZONA · PI DURYEA, JEFFREY W, KWOH, C KENT · 2021 to 2022
$2.4M
The longitudinal relationship of sedentary behavior with health outcomes in a community-based cohort: The Johnston County Health StudyR56AR080060 · NIAMS · UNIVERSITY OF DELAWARE · PI WHITE, DANIEL K · 2022 to 2022
$701k
Optimizing Osteoarthritis Care through Clinical and Community PartnershipR21AR080309 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ALLEN, KELLI D. · 2022 to 2023
$547k
Understanding the Neurophysiology of Ankle Instability to Improve Rehabilitation OutcomesR15AG085105 · NIA · UNIVERSITY OF NEBRASKA OMAHA · PI ROSEN, ADAM B · 2024 to 2024
$446k
STepped Exercise Program for Knee Osteoarthritis: The STEP-KOA StudyR34AR083077 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ALLEN, KELLI D., GOLIGHTLY, YVONNE M · 2024 to 2025
$407k
Osteoarthritis After ACL Injury: Establishing Cumulative Joint Loading as a Preventative TargetR21AR075254 · NIAMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI WELLSANDT, ELIZABETH A · 2020 to 2021
$373k
NIAMS NIH HHS P30 AR072580NIAMS NIH HHS R01 AR078187NIAMS NIH HHS R01 AR080346NIAMS NIH HHS R01 AR080733NIAMS NIH HHS R01 AR080742NIAMS NIH HHS R21 AR075254NIAMS NIH HHS R21 AR080309NIAMS NIH HHS R34 AR083077NIAMS NIH HHS R56 AR080060NIA NIH HHS R15 AG085105NIGMS NIH HHS U54 GM115458
6 · The paper itself

Abstract

introduction/purposeFemales have lower physical activity (PA) levels and inferior outcomes compared with males following formal rehabilitation after anterior cruciate ligament (ACL) reconstruction. This observational study aimed to determine if PA levels and sedentary behavior change and vary by sex during the time before and 6 months after ACL reconstruction.

methodsPA and sedentary behavior were measured in an observational cohort of 30 participants (19.6 ± 4.9 yr old, 66.7% female) using a three-axis accelerometer before (preoperative) and at 2, 4, and 6 months after ACL reconstruction. Daily steps, daily minutes of moderate to vigorous PA (MVPA), and percentage of wake time in sedentary behavior (%SED) were measured. Two-by-four (sex-time) repeated measures analyses of variance were used to test changes in PA and %SED.

resultsIn females and males, daily steps and MVPA increased from 2 to 4 months after ACL reconstruction (all P < 0.05) but not between other consecutive time points. %SED did not change between any consecutive time points. At 6 months, females walked fewer daily steps ( P = 0.002; females: 7003 ± 2068; males: 10,406 ± 3277), spent fewer minutes in MVPA ( P = 0.010; females: 31.3 ± 14.6; males: 54.9 ± 32.4), and spent more time in %SED ( P = 0.003; females: 67.9 ± 7.4; males: 57.5 ± 9.5).

conclusionsPA levels increased in females and males from 2 to 4 months after ACL reconstruction but not between other consecutive time points from before through 6 months after surgery. Females completed less PA and spent more time in sedentary behavior than males and may require greater monitoring to improve PA after ACL reconstruction. The disparity in PA and sedentary behavior across sex follows consistent previous findings that outcomes after ACL reconstruction are poorer in females compared with males.

Indexed as

Anterior Cruciate Ligament ReconstructionExerciseSedentary BehaviorAccelerometryAdolescentAdultAnterior Cruciate Ligament InjuriesFemaleHumansMaleSex FactorsTime FactorsYoung AdultACLEXERCISEKNEEREHABILITATIONWALKING

Identifiers

PMID40176279
PMCPMC12723752

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.