ArticleRespirology (Carlton, Vic.)2025
Associations Between Occupational Exposures and Cough Subclasses Among Middle-Aged Australians.
Article in Respirology (Carlton, Vic.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Civilian Occupational Exposure to Vapors, Gas, Dust, or Fumes and Respiratory Health Among United States Military Veterans.American journal of industrial medicine · 2026Article
- Associations Between Occupational Exposures and Cough Subclasses Among Middle-Aged Australians.Respirology (Carlton, Vic.) · 2025Article
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15 authors.
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Abstract
BACKGROUND AND
objectiveThe evidence around occupation-related chronic cough is conflicting and current definitions of chronic cough cannot capture its heterogeneity. Using our recently characterised novel cough subclasses, we aimed to identify subclass-specific occupational risks.
methodsUsing data from the Tasmanian Longitudinal Health Study (TAHS), occupational exposures up to age 53 years were coded using the ALOHA+ Job Exposure Matrix, into ever-exposure (no, only-low, ever-high) and cumulative exposure. People belonging to six previously identified cough subclasses among 2213 current coughers at age 53 years were compared to non-coughers (n = 1396). Associations with occupational exposures were assessed using multinomial logistic regression for these cough subclasses and logistic regression for standard definitions (chronic cough, chronic phlegm, and chronic bronchitis) after adjusting for potential confounders.
resultsBiological dust was associated with "cough with allergies" (cumulative: adjusted multinomial odds ratio [aMOR] = 1.06, 95% CI: 1.02-1.10, per 10 exposure-year increase). Aromatic solvents were associated with "chronic dry cough" (cumulative: aMOR = 1.15, 95% CI: 1.02-1.29). Other solvents were associated with "chronic productive cough" (ever-high: aMOR = 2.81, 95% CI: 1.26-6.2); "intermittent productive cough" (cumulative: aMOR = 1.06, 95% CI: 0.98-1.16), chronic bronchitis (ever-high: aOR = 2.48, 95% CI: 1.01-6.06); and chronic phlegm (ever-high: aOR = 2.26, 95% CI: 1.14-4.51). Herbicides (cumulative) were also associated with "intermittent productive cough" (aOR = 1.09, 95% CI: 1.00-1.77) and chronic phlegm (aOR = 1.07, 95% CI: 1.00-1.15).
conclusionNovel cough subclasses had distinct associations with specific occupational exposures, suggesting different pathophysiology. Aromatic solvents were associated with dry cough; biological dust with allergic cough; herbicides and other solvents with productive cough. Using novel cough subclasses was superior to standard definitions in uncovering these associations.
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