ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2026
Trends in Anaplasmosis Over the Past Decade: A Review of Clinical Features, Laboratory Data, and Outcomes.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Cardiovascular Complications of Anaplasmosis: A Case of Acute Pulmonary Embolism and Literature Review.Infectious disease reports · 2026Article
- Cerebrospinal Fluid Findings among Patients with Anaplasmosis and Central Nervous Involvement, Minnesota and Wisconsin, USA.Emerging infectious diseases · 2026Article
- Comparative Clinical Characteristics of ICU and Non-ICU Hospitalized Patients With Human Anaplasmosis.Open forum infectious diseases · 2026Article
- Article
- Retrospective Multicenter Study of Human Granulocytic Anaplasmosis, France, 2012-2024.Emerging infectious diseases · 2025Article
- Update on North American tick-borne diseases and how to diagnose them.Journal of clinical microbiology · 2025Review
- Article
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Authors and funding
8 authors.
Funding
Abstract
backgroundThere is a lack of comprehensive, large cohort studies investigating the predictors for severity and hospitalization in human granulocytic anaplasmosis (HGA).
methodsWe conducted a retrospective cohort study including all cases of HGA identified by positive blood Anaplasma polymerase chain reaction (PCR) at the Mayo Clinic Laboratory, Rochester between 2011 and 2021. Multivariable logistic regression was performed to evaluate risk factors associated with hospitalization.
resultsA total of 465 cases were identified. Of those, 67% (n = 312) were managed in the outpatient setting. Hospitalized patients (n = 153, 33%) were more likely to be older (median age of 71 vs 61; P ≤ .001) and immunocompromised (17% vs 7%; P ≤ .001). The triad of leukopenia, thrombocytopenia, and transaminitis was observed in 24% of the cases, but was associated with risk of hospitalization (odds ratio [OR] 1.78, 95% confidence interval [CI]: 1.05-3.03; P ≤ .033). The presence of a coinfection did not impact mortality or hospitalization.
conclusionsThe risk factors for hospitalization in patients with HGA include altered mental status, higher absolute neutrophil count (ANC), advanced age, comorbidities, and immunosuppression. The classic hematological and biochemical profile may be absent in the majority of cases. Co-testing may be of higher benefit in select cases.
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