ArticleVirology journal2025
Identification and characterization of a novel reovirus strain isolated fromgrass carp (Ctenopharyngodon idella).
Article in Virology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Protective Efficacy of Vaccines Against Grass Carp Hemorrhagic Disease: A Systematic Review and Meta-Analysis.Journal of fish diseases · 2026Pooled it
- Hnf4α integrates AIF and caspase 3/9 signaling to restrict single and coinfecting pathogens in teleosts.PLoS pathogens · 2025Article
- Genome-wide identification of the interferon complex establishes IFNf in Cypriniformes.BMC biology · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundGrass carp (Ctenopharyngodon idella) hemorrhagic disease (GCHD) is a devastating disease that leads to substantial economic losses in the freshwater aquaculture industry.
resultsIn this study, we investigated an outbreak of GCHD in large-scale grass carp and identified GCRV-II infection. Notably, hematoxylin and eosin (H&E) staining showed severe histopathological changes in the spleen, head kidney, gill, and gut. Furthermore, we sequenced the entire genome of the viral isolate, and multiple sequence alignment and phylogenetic tree analysis indicated that it represents a novel strain of GCRV-II, provisionally named GCRV-YX246. Finally, artificial infection experiments confirmed the strong virulence, high mortality, and severe pathological damage caused by GCRV-YX246, as demonstrated through artificial infection.
conclusionsA novel reovirus from large-scale grass carp cultured in China was identified. The discovery of this novel GCRV-II strain enhances our understanding of GCRV-II biology and provides valuable insights for developing more effective prevention strategies for GCHD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.