ReviewDiagnostic pathology2025
Microsecretory adenocarcinoma: simplifying the diagnosis of a recently recognized salivary gland and cutaneous adnexal neoplasm.
Review in Diagnostic pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- S1 guideline sweat gland carcinoma.Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2026Guideline
- Comprehensive comparison of salivary gland and cutaneous adnexal tumors: analogous versus discrepant clinical, terminological, histological, and molecular features : Part II: Second series of related tumor entities and synoptic comparison of general aspects.Virchows Archiv : an international journal of pathology · 2026Review
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3 authors.
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Abstract
backgroundMicrosecretory adenocarcinoma (MSA) is a newly identified entity in the WHO classification of salivary gland tumors characterized by MEF2C::SS18 fusion. It was previously considered as adenocarcinoma not otherwise specified (NOS). With the discovery of new gene fusions specifying distinct salivary gland tumors and restricting the diagnosis of adenocarcinoma NOS, five cases of MSA were recognized for the first time using targeted RNA sequencing. Afterwards, further authors reported MSA in the salivary glands and more recently in the skin.
methodsWe reviewed the literature for all cases of MSA reported in English-language articles. We comprehensively discussed clinical, histopathological, immunohistochemical and molecular findings of the retrieved cases.
resultsForty cases were identified. Thirty cases occurred in the salivary glands and ten cases occurred in the skin. They were characterized histologically by a well circumscribed mass formed of microcysts containing basophilic secretions and enclosed in a fibromyxoid stroma. The tumor cells were flattened resembling intercalated duct cells with minimal eosinophilic cytoplasm and small oval nuclei. By immunohistochemistry, the tumor cells were positive for SOX10, S100, p63 and negative for p40, calponin and mammaglobin. However, cutaneous cases had a somewhat different immunoprofile.
conclusionMSA is a salivary gland malignancy that also has a cutaneous counterpart. Focusing on emphasising the almost consistent histopathological and immunohistochemical findings help in increasing the awareness of clinicians, surgeons and pathologists about it and at the same time lessening the need for more complicated diagnostic methods that are not readily available in all institutions. Despite the low-grade nature of this tumor, thorough management and rigorous follow up of cases are highly recommended due to occasional aggressive behaviour.
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