ArticleCardiovascular diabetology2025
Elevated triglyceride-glucose index is a risk factor for cardiovascular events in adults with type 1 diabetes: a cohort study.
Article in Cardiovascular diabetology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The efficacy and safety of Fuzheng traditional Chinese medicine injections in the treatment of acute ischemic stroke: a systematic review and network meta-analysis.Frontiers in pharmacology · 2025Pooled it
- Association of the C-reactive protein-triglyceride glucose index with new-onset myocardial infarction risk: a prospective cohort study.Scientific reports · 2026Article
- Association of Triglyceride-Glucose-Frailty Index with Cardiovascular Disease and All-Cause Mortality Incidence in Individuals with Cardiovascular-Kidney-Metabolic Syndrome Stages 0-3: A Nationwide Prospective Cohort Study.Journal of clinical medicine · 2026Article
- Estimated glucose disposal rate and risk of first myocardial infarction in people with diabetes.Cardiovascular diabetology. Endocrinology reports · 2026Article
- Association of Triglyceride-Glucose Index With In-Hospital Malignant Arrhythmias in Older Patients With Diabetes Mellitus and Left Ventricular Aneurysm: A Retrospective Study.Reviews in cardiovascular medicine · 2026Article
- Highly Uncontrolled Cardiovascular Risk in Emerging Adults With Paediatric-Onset Type 1 Diabetes-A Cross-Sectional Analysis From the Diabetes Prospective Follow-Up Registry DPV.Diabetes, obesity & metabolism · 2026Article
- The obesity paradox effect of triglyceride-glucose-body mass index (TyG-BMI) on all-cause mortality in patients with malignant tumors: a machine learning-driven cohort study.Translational cancer research · 2026Article
- Association between triglyceride-glucose index and diabetic kidney disease in adults with type 1 diabetes.BMC endocrine disorders · 2026Article
- Elevated triglyceride-glucose index is associated with increased risk of chronic kidney disease and end-stage renal disease in type 1 diabetes: Nationwide cohort study.Diabetes, obesity & metabolism · 2026Article
- Association of cumulative cholesterol-HDL-glucose index with blood pressure changes and risk of new-onset hypertension in middle-aged and older adults: a cohort study.Cardiovascular diabetology · 2026Article
- Association of the preoperative triglyceride-glucose index with postoperative atrial fibrillation following esophagectomy: a retrospective cohort study with a focus on non-diabetic patients.Frontiers in nutrition · 2026Article
- Association of triglyceride-glucose index and high-sensitivity C-reactive protein with contrast-induced nephropathy after percutaneous coronary intervention in patients with acute coronary syndrome: a retrospective cohort study.Frontiers in cardiovascular medicine · 2026Article
- Impact of TyG index on coronary plaques in patients with coronary artery disease under aggressive lipid-lowering therapy.Frontiers in endocrinology · 2026Observational
- Systemic effects of type 2 diabetes therapies: an integrated perspective on the cardio-renal- cerebral-metabolic axis.Frontiers in medicine · 2026Review
- A body shape index combined with the triglyceride-glucose index for cardiovascular risk prediction in overweight and obese Chinese adults.Frontiers in cardiovascular medicine · 2026Article
- Associations of the Triglyceride-Glucose Index and Body Fat Composition with Blood Pressure in Children and Adolescents.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2025Article
- The Triglyceride-Glucose Index: A Practical Tool for Enhanced Cardiovascular Risk Stratification in Type 2 Diabetes.Endocrinology and metabolism (Seoul, Korea) · 2025Article
- C-reactive protein-triglyceride glucose index in evaluating cardiovascular disease and all-cause mortality incidence among individuals across stages 0-3 of cardiovascular-kidney-metabolic syndrome: a nationwide prospective cohort study.Cardiovascular diabetology · 2025Article
- Exploring BMI's mediating influence on cardiovascular risk correlations with the triglyceride-glucose index: using NHANES and CHARLS cohorts.Frontiers in cardiovascular medicine · 2025Article
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Abstract
backgroundThe triglyceride-glucose (TyG) index is recognized as an indicator of insulin resistance and is linked to cardiovascular disease (CVD) in patients with type 2 diabetes. However, its utility in patients with Type 1 diabetes (T1DM) has not been studied.
methodsIn this nationwide cohort study, we enrolled 14,543 patients with T1DM between 2009 and 2015, with a median follow-up duration of 7.52 years. The primary outcome was the incidence of CVD, including myocardial infarction, ischemic stroke, and heart failure. The secondary outcome was the all-cause mortality. The risk of CVD across the TyG index quartiles was compared using the Cox proportional hazards model.
resultsThe cut-off points for the TyG quartiles were 8.46, 9.03, and 9.60. Patients in the highest TyG quartile exhibited a higher burden of cardiometabolic risk factors, including obesity, hypertension, dyslipidemia, and lower HDL cholesterol levels. Compared to the lowest quartile, the highest TyG quartile group showed a significantly increased risk of CVD (Composite CVD: adjusted hazard ratio [aHR] = 1.80; 95% confidence interval [CI] = 1.62-2.00, myocardial infarction: aHR = 1.70;95% CI = 1.38-2.10, ischemic stroke: aHR = 2.11; 95% CI = 1.78-2.50, heart failure: aHR = 1.65, 95% CI = 1.45-1.88) and all-cause mortality (aHR = 1.60, 95% CI = 1.41-1.81).
conclusionsA higher TyG index was significantly associated with an increased risk of CVD and all-cause mortality in patients with T1DM. RESEARCH INSIGHTS: What is currently known about this topic? 1. The TyG index is associated with insulin resistance and cardiovascular disease in both patients with type 2 diabetes and the general population. What is the key research question? 1. Could the TyG index also be utilized to assess insulin resistance and cardiovascular disease risk in patients with type 1 diabetes? What is new? 1. In patients with type 1 diabetes, those in the higher TyG quartile showed a higher prevalence of metabolic dysfunction such as obesity, hypertension and dyslipidemia. 2. A higher TyG index in patients with type 1 diabetes was associated with an increased risk of all-cause mortality and cardiovascular disease including myocardial infarction, heart failure and stroke. How might this study influence clinical practice? 1. The TyG index, a simple and non-invasive marker composed of triglycerides and fasting glucose, could be used to identify patients with type 1 diabetes who have high insulin resistance and cardiovascular disease risk.
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