SynthesisWorld journal of surgical oncology2025
Prognostic and clinicopathological significance of C-reactive protein-albumin-lymphocyte(CALLY) in patients with digestive system neoplasms: a systematic review and meta-analysis.
Synthesis in World journal of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prognostic Value of the C-Reactive Protein-Albumin-Lymphocyte Index in Hepatobiliary and Pancreatic Cancers: A Systematic Review and Meta-Analysis.Journal of gastrointestinal cancer · 2026Pooled it
- Prognostic Value of Pretreatment C-Reactive-Protein-Albumin-Lymphocyte Index in Colorectal Cancer: Systematic Review and Meta-Analysis.Journal of gastrointestinal cancer · 2026Pooled it
- Article
- Is the CALLY Index the Best Tool for Predicting Survival in Patients with Primary Soft Tissue Sarcomas?Diagnostics (Basel, Switzerland) · 2026Article
- C-Reactive Protein-Albumin-Lymphocyte Index and the Modified Glasgow Prognostic Score as Predictors of Early Mortality After Palliative Percutaneous Transhepatic Biliary Drainage in Malignant Biliary Obstruction.Journal of clinical medicine · 2026Article
- Attack-Related Anticipatory Anxiety Symptoms in Familial Mediterranean Fever: An Exploratory Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2026Article
- Machine Learning-Driven Prognostic Model Integrating Lymphocyte-to-C-Reactive Protein Ratio and TNM Staging in Gallbladder Cancer.Cancer medicine · 2026Article
- The C-Reactive Protein-Albumin-Lymphocyte (CALLY) Index as an Independent Predictor of Progression and Survival in Metastatic Renal Cell Carcinoma.Journal of clinical medicine · 2026Article
- The Role of the CALLY Index in 30-Day Mortality Prediction for Acute Mesenteric Ischemia: A Retrospective Cohort Study.Medicina (Kaunas, Lithuania) · 2026Article
- Pretreatment CRP-Albumin-Lymphocyte (CALLY) Index as a Prognostic Biomarker of Survival and Recurrence-Free Survival in Patients With Early-Stage Cervical Cancer After Radical Hysterectomy: A Multicenter Retrospective Cohort Study.Obstetrics and gynecology international · 2026Article
- Diagnostic value of C-reactive protein-albumin-lymphocyte index in breast cancer cases.Frontiers in oncology · 2026Article
- BMI mediates the association of CALLY index with liver steatosis and fibrosis.Scientific reports · 2025Article
- Prognostic Value of CRP-Albumin-Lymphocyte (CALLY) Index in Colorectal Cancer Survival: A Multicenter Retrospective Cohort Study.Journal of gastrointestinal cancer · 2025Article
- Oxidative Stress and Inflammation: Drivers of Tumorigenesis and Therapeutic Opportunities.Antioxidants (Basel, Switzerland) · 2025Review
- Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
objectiveThe prognostic significance of the C-reactive protein-albumin-lymphocyte (CALLY) index in digestive system neoplasms (DSNs) has been investigated in several studies, but inconsistencies remain between the results of different studies. Therefore, the aim of this study was to confirm the prognostic significance of CALLY in patients with DSNs and its association with clinicopathological characteristics (CPCs).
methodsThe databases PubMed, Cochrane Library, Web of Science, Research Square and Embase were systematically searched for clinical trials with databases up to 1 November 2024. The value of CALLY in predicting overall survival (OS), disease-free survival (DFS) and recurrence-free survival (RFS) versus cancer-specific survival (CSS) in patients with DSNs was confirmed by calculating the combined hazard ratio (HR) and 95% CI. The combined OR and 95% CI were calculated to assess the association between CALLY and CPCs in patients with DSNs.
resultsA total of 18 studies with 7916 patients with DSNs were included in this study. Pooled analysis showed that lower CALLY was associated with poor OS, DFS, RFS and CSS were significantly associated. In addition, low CALLY index was associated with male gender, T3-T4, lymph node metastasis, lymph vessel invasion, complications, stage III-IV and surgical approach were significantly associated. However, there was no association between low CALLY index and histological type, adjuvant chemotherapy, and neoadjuvant chemotherapy.
conclusionsIn this meta-analysis, a low CALLY index was significantly associated with poor OS, DFS, RFS and CSS in patients with DSNs and with several CPCs in patients with DSNs. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42024622973.
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