Evidence map›Paper›PMID 40175914›Full record

ArticleBMC medical imaging2025

Incidence and features of pulmonary track nodules after CT-guided lung biopsy with track sealing using gelatin sponge slurry.

Flavien Grandjean, Nadia Withofs, Nancy Detrembleur, Laurent Gérard, Pierre Lamborelle, Christophe Valkenborgh, Nadia Dardenne, François Cousin

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In one paragraph

Article in BMC medical imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Flavien GrandjeanDepartment of Imaging, University Hospital of Liège, Avenue de l'Hôpital 1, Liège, 4000, Belgium.
Nadia WithofsDepartment of Nuclear Medicine and Oncological Imaging, University Hospital of Liège, Avenue de l'Hôpital 1, Liège, 4000, Belgium.
Nancy DetrembleurDepartment of Pathology, University Hospital of Liège, Avenue de l'Hôpital 1, Liège, 4000, Belgium.
Laurent GérardDepartment of Imaging, University Hospital of Liège, Avenue de l'Hôpital 1, Liège, 4000, Belgium.
Pierre LamborelleDepartment of Imaging, University Hospital of Liège, Avenue de l'Hôpital 1, Liège, 4000, Belgium.
Christophe ValkenborghDepartment of Imaging, University Hospital of Liège, Avenue de l'Hôpital 1, Liège, 4000, Belgium.
Nadia DardenneUniversity and Hospital Biostatistics Center (B-STAT), University of Liège, Liège, 4000, Belgium.
François CousinDepartment of Nuclear Medicine and Oncological Imaging, University Hospital of Liège, Avenue de l'Hôpital 1, Liège, 4000, Belgium. fcousin@chuliege.be.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTrack sealing (TS) with gelatin sponge slurry (GSS) is efficient in reducing pneumothorax after CT-guided lung biopsy. Nodule appearance along the pulmonary track after TS with GSS is a potential issue that has not been previously evaluated.

methodsA secondary analysis of two studies evaluating the efficacy of lung TS in 710 patients in reducing post-biopsy pneumothorax was performed. Among these patients, 377 had a follow-up CT within 2 months post-biopsy and were retrospectively included in this study (187 had TS with GSS, 83 with saline, and 107 no TS). Imaging findings of the pulmonary track were described. Binary logistic regression was used to determine factors associated with lung track nodules.

resultsMedian time between biopsy and follow-up CT was 29 days (range, 1-61). A pulmonary track nodule was detected on follow-up CT in 65/377 (17.2%) patients. Sixty three out of these 65 nodules (97%) were observed in the GSS group. Factors significantly associated with nodules on multivariate analysis were GSS use (odds ratio: 47.4, 95%CI:11.8-189.5; p < .0001) and track length (odds ratio: 1.03, 95%CI:1.01-1.05; p = .009). Nodules were solid in 100%, ovoid in 83.1%, well-defined in 87.7%, and had smooth borders in 96.9%. Thirty-three nodules were still visible on imaging > 6 weeks after the biopsy.

conclusionA pulmonary nodule along the biopsy track was detected on follow-up CT in 34% of cases when TS with GSS was performed. Recognition of these nodules on chest imaging is essential to avoid misinterpretation. CLINICAL TRIAL NUMBER: Not applicable.

Indexed as

Image-Guided BiopsyLung NeoplasmsPneumothoraxSolitary Pulmonary NoduleTomography, X-Ray ComputedAdultAgedAged, 80 and overFemaleGelatinHumansIncidenceLungMaleMiddle AgedRetrospective StudiesGelatinCT-guided lung biopsyGelatin spongePneumothoraxTrack sealant

Identifiers

PMID40175914
PMCPMC11963371

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.