Evidence map›Paper›PMID 40175907›Full record

ArticleBMC cardiovascular disorders2025

High triglyceride-to-high-density lipoprotein cholesterol ratio predicts poor prognosis in new-onset heart failure: a retrospective study.

Junfei Weng, Wei Dong, Ruichun Liao, Yaofu Zheng, Xu Fang, Jiaxiang You, Zhichao Wang, Yingbing Zuo, Xuanying Chen, Xiaoping Peng

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In one paragraph

Article in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

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4citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Junfei Weng *The 1 st affiliated hospital, Jiangxi Medical College, Nanchang University, No. 461, Bayi Avenue, Nanchang City, 330006, Jiangxi Province, People's Republic of China.
Wei Dong *The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 17, Yongwaizheng Street, Donghu District, Nanchang City, 330006, Jiangxi Province, People's Republic of China.
Ruichun Liao *The 1 st affiliated hospital, Jiangxi Medical College, Nanchang University, No. 461, Bayi Avenue, Nanchang City, 330006, Jiangxi Province, People's Republic of China.
Yaofu Zheng *The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 17, Yongwaizheng Street, Donghu District, Nanchang City, 330006, Jiangxi Province, People's Republic of China.
Xu Fang *The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 17, Yongwaizheng Street, Donghu District, Nanchang City, 330006, Jiangxi Province, People's Republic of China.
Jiaxiang You *The 1 st affiliated hospital, Jiangxi Medical College, Nanchang University, No. 461, Bayi Avenue, Nanchang City, 330006, Jiangxi Province, People's Republic of China.
Zhichao WangThe First Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 17, Yongwaizheng Street, Donghu District, Nanchang City, 330006, Jiangxi Province, People's Republic of China.
Yingbing ZuoThe 1 st affiliated hospital, Jiangxi Medical College, Nanchang University, No. 461, Bayi Avenue, Nanchang City, 330006, Jiangxi Province, People's Republic of China.
Xuanying ChenThe First Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 17, Yongwaizheng Street, Donghu District, Nanchang City, 330006, Jiangxi Province, People's Republic of China.
Xiaoping PengThe First Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 17, Yongwaizheng Street, Donghu District, Nanchang City, 330006, Jiangxi Province, People's Republic of China. cdyfypxp@163.com.

Funding

National Nature Science Foundation of China 8206020488
6 · The paper itself

Abstract

backgroundThere is limited research on the relationship between the triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio and outcomes in new-onset heart failure (HF). Therefore, this study aimed to explore the association between TG/HDL-C ratio and clinical outcomes in these patients.

methodsA retrospective cohort of 614 adults with new-onset HF hospitalized at The First Affiliated Hospital of Nanchang University between July 2021 and December 2022 was analyzed. The primary endpoint was major adverse cardiovascular events (MACE), defined as cardiovascular (CV) death and HF rehospitalizations within 12 months after discharge. Kaplan-Meier (K-M) curves, restricted cubic spline (RCS) analysis, and Cox regression evaluated the association between TG/HDL-C ratio and MACE risk.

resultsPatients were divided into four quartiles (Quartile 1, 2,3 and 4) based on their TG/HDL-C ratios. The mean age was 68.94 ± 14.34 years, with 59.12% male. The mean left ventricular ejection fraction (LVEF) was 46.59 ± 10.89%, with 45.11% having an LVEF ≤ 40%. During the 12-month follow-up, 156 patients experienced MACE, comprising 18 CV deaths and 138 HF rehospitalizations. The Quartile 4 group had the highest MACE risk incidence compared to other groups (P < 0.001). K-M analysis confirmed that the Quartile 4 group was associated with an increased cumulative incidence of MACE, HF rehospitalization, and CV death (all P < 0.001). RCS analysis revealed a positive nonlinear relationship between the TG/HDL-C ratio and MACE risk (P for nonlinear = 0.026), with a sharp risk increase above a ratio of 1.08. After adjustment, TG/HDL-C ratio was independently associated with MACE (HR: 1.44, 95% CI: 1.29-1.60). Compared to Quartile 1, adjusted HRs were significantly higher in Quartiles 2, 3, and 4 (all P < 0.005).

conclusionsThe TG/HDL-C ratio is independently associated with 12-month MACE risk in new-onset HF patients. It may serve as a simple, cost-effective marker to improve early risk stratification and guide closer monitoring and tailored management in this high-risk population.

Indexed as

Cholesterol, HDLDyslipidemiasHeart FailureTriglyceridesAgedBiomarkersChinaFemaleHumansMaleMiddle AgedPatient ReadmissionPredictive Value of TestsPrognosisRetrospective StudiesRisk AssessmentBiomarkersCholesterol, HDLTriglyceridesNew-onset heart failureNonlinear associationPoor prognosisTriglyceride-to-high-density lipoprotein cholesterol ratio

Identifiers

PMID40175907
PMCPMC11963554

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.