Evidence map›Paper›PMID 40175810›Full record

ArticleAMB Express2025

Gut microbiota, blood metabolites, & pan-cancer: a bidirectional Mendelian randomization & mediation analysis.

Biqing Luan, Yang Yang, Qizhi Yang, Zhiqiang Li, Zhihui Xu, Yaqin Chen, Meiting Wang, Wenlin Chen, Fei Ge

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AMB Express, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Biqing Luan *Department of Breast Surgery, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Yang Yang *Yunnan Key Laboratory of Breast Cancer Precision Medicine, Department of breast surgery, The Third Affiliated Hospital of Kunming Medical University, Peking University Cancer Hospital Yunnan, Yunnan Cancer Hospital, Kunming, Yunnan, China.
Qizhi YangDepartment of Breast Surgery, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Zhiqiang LiDepartment of Breast Surgery, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Zhihui XuDepartment of Breast Surgery, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Yaqin ChenDepartment of Breast Surgery, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Meiting WangDepartment of Breast Surgery, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Wenlin ChenYunnan Key Laboratory of Breast Cancer Precision Medicine, Department of breast surgery, The Third Affiliated Hospital of Kunming Medical University, Peking University Cancer Hospital Yunnan, Yunnan Cancer Hospital, Kunming, Yunnan, China. chenwenlin1@hotmail.com.
Fei GeDepartment of Breast Surgery, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China. ajqnadjd@hotmail.com.ORCID http://orcid.org/0000-0002-1561-2785

Funding

National Natural Science Foundation of China 82060538National Natural Science Foundation of China 82060543
6 · The paper itself

Abstract

We propose using Mendelian randomization analysis on GWAS data and MetaboAnalyst to model gut microbiota, metabolic pathways, blood metabolites, and cancer risk. We examined 473 gut microbiota, 205 pathways, 1400 metabolites, and 8 cancers. Results were validated through bidirectional two-sample Mendelian Randomization (MR), heterogeneity tests, and pathway enrichment, leading to a mediation pathway model. We identified 129 gut microbiota, 57 pathways, and 463 metabolites linked to cancer, and 34 significant plasma pathways. 15 microbiota, 8 pathways, and 58 metabolites implicated in multiple cancers. Eight plasma metabolic pathways are involved in the development of multiple types of cancer. Through Multivariate Mendelian Randomization (MVMR) and mediation analysis, we found 9 mediation pathways, offering novel targets and research directions for cancer pathogenesis and treatment.

Indexed as

Blood metabolitesGut microbiotaMediation analysisMendelian randomizationMetabolic pathway enrichment analysisPan-cancer

Identifiers

PMID40175810
PMCPMC11965084

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.