Evidence map›Paper›PMID 40175809›Full record

ArticleAdvanced biotechnology2025

Electrostatic charge at the biomaterial-pathogen interface influences antibiotic efficacy.

Andrew Hayles, Huu Ngoc Nguyen, Markos Alemie, Jitraporn Vongsvivut, Neethu Ninan, Richard Bright, Panthihage Ruvini Dabare, Christopher Gibson, Vi Khanh Truong, Krasimir Vasilev

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Andrew HaylesBiomedical Nanoengineering Laboratory, Flinders University, Bedford Park, SA, 5042, Australia. andrew.hayles@flinders.edu.au.ORCID http://orcid.org/0000-0001-7247-8271
Huu Ngoc NguyenBiomedical Nanoengineering Laboratory, Flinders University, Bedford Park, SA, 5042, Australia.
Markos AlemieBiomedical Nanoengineering Laboratory, Flinders University, Bedford Park, SA, 5042, Australia.
Jitraporn VongsvivutInfrared Microspectroscopy (IRM) Beamline, ANSTO ‒ Australian Synchrotron, 800 Blackburn Road, Clayton, VIC, 3168, Australia.
Neethu NinanBiomedical Nanoengineering Laboratory, Flinders University, Bedford Park, SA, 5042, Australia.
Richard BrightBiomedical Nanoengineering Laboratory, Flinders University, Bedford Park, SA, 5042, Australia.
Panthihage Ruvini DabareAcademic Unit of STEM, University of South Australia, Mawson Lakes, SA, 5095, Australia.
Christopher GibsonFlinders Microscopy and Microanalysis, Flinders University, Bedford Park, SA, 5042, Australia.
Vi Khanh TruongBiomedical Nanoengineering Laboratory, Flinders University, Bedford Park, SA, 5042, Australia.
Krasimir VasilevBiomedical Nanoengineering Laboratory, Flinders University, Bedford Park, SA, 5042, Australia. krasimir.vasilev@flinders.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Implant-associated infections (IAI) are a considerable burden for healthcare systems globally. While novel anti-infective biomaterials are being pursued, prophylactic antibiotic treatment remains the most important intervention for mitigating IAI. The antibiotic tolerance of bacteria has been widely studied, but until recently, the contributions of biomaterial-pathogen interactions have been overlooked. In the present study, we investigate how material electrostatic charge influences the physiological state of the most clinically challenging pathogen-Staphylococcus aureus, and the implications on its antibiotic tolerance. We utilized a combination of techniques, including quantitative gene expression and synchrotron-sourced attenuated total reflectance Fourier-transform microspectroscopy, to characterize this phenomenon - elucidating how surface attachment to differently charged substrates drives the pathogen to modify its phenotype. Subsequently, we found a direct relationship between the activity of oppositely charged antibiotics (vancomycin and cefazolin) and the biomaterial-pathogen interface, which we determined to be governed by material electrostatic properties. The findings of the present study have the potential to inform the development of enhanced procedures of antibiotic prophylaxis by instructing personalized biomaterial-antibiotic pairing strategies. These new insights hold promise to contribute to reducing the rate of IAI by enabling clinicians and surgeons to maximize the efficacy of prophylactic antibiotic treatments during implant placement procedures.

Indexed as

Antibiotic prophylaxisBiomaterialsCoatingDrug toleranceNanotechnologySurface charge

Identifiers

PMID40175809
PMCPMC11965051

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.