ArticleJournal of fluorescence2025
Synthesis, Characterization, and Biomolecular Interactions of a novel Copper(II) Complex: DNA and BSA Binding Studies.
Article in Journal of fluorescence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This study synthesizes and characterizes the mononuclear complex [Cu(phen)₂(NO₃)]NO₃·H₂O using analytical techniques such as infrared spectroscopy (FT-IR), elemental analysis, molar conductivity measurements, and single-crystal X-ray crystallography. The complex exhibited 1:1 electrolyte behavior. X-ray crystallography revealed a distorted trigonal bipyramidal geometry around Cu(II), stabilized by two 1,10 phenanthroline ligands and a nitrate ion. Crystallographic data were further analyzed using Hirshfeld surface analysis to quantify intermolecular interactions. The analysis revealed the following percentages: O…H (30.3%) and H…H (25.6%). DNA binding studies using UV-vis absorption spectroscopy demonstrated a hypochromic effect, suggesting a partial intercalative or groove-binding mode due to steric hindrance. The binding constant (K
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