Evidence map›Paper›PMID 40175790›Full record

ReviewNeurotoxicity research2025

Exploring the potential role of microtubule associated proteins-2 in the pathogenesis of HIV associated neurocognitive disorders.

Melanie K Becher, Valeria Avdoshina, Lee A Campbell, Italo Mocchetti

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neurotoxicity research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Melanie K BecherInterdisciplinary Program in Neuroscience and Laboratory of Preclinical Neurobiology, Department of Neuroscience, Georgetown University Medical Center, WP13 New Research Building, 3970 Reservoir Rd, NW, Washington, DC, 20057, USA.ORCID http://orcid.org/0000-0002-7249-0032
Valeria AvdoshinaInterdisciplinary Program in Neuroscience and Laboratory of Preclinical Neurobiology, Department of Neuroscience, Georgetown University Medical Center, WP13 New Research Building, 3970 Reservoir Rd, NW, Washington, DC, 20057, USA.
Lee A CampbellInterdisciplinary Program in Neuroscience and Laboratory of Preclinical Neurobiology, Department of Neuroscience, Georgetown University Medical Center, WP13 New Research Building, 3970 Reservoir Rd, NW, Washington, DC, 20057, USA.
Italo MocchettiInterdisciplinary Program in Neuroscience and Laboratory of Preclinical Neurobiology, Department of Neuroscience, Georgetown University Medical Center, WP13 New Research Building, 3970 Reservoir Rd, NW, Washington, DC, 20057, USA. moccheti@georgetown.edu.ORCID http://orcid.org/0000-0002-5010-636X

Funding

Role of proBNDF and p75NTR in HIV-mediated Axonal/Dendritic DegenerationR01NS079172 · NINDS · GEORGETOWN UNIVERSITY · PI Italo Mocchetti · 2012 to 2026
$7.0M
Training Program in NeuroHIV (TPNH)T32NS121780 · NINDS · GEORGETOWN UNIVERSITY · PI Marta L. Catalfamo, Italo Mocchetti · 2021 to 2026
$894k
HIV promotes dendritic degeneration by altering microtubule-associated proteinR21NS131097 · NINDS · GEORGETOWN UNIVERSITY · PI MOCCHETTI, ITALO · 2022 to 2022
$429k
Gp120 binds to neuronal microtubules: a new mechanism for synaptic simplificationR21NS104000 · NINDS · GEORGETOWN UNIVERSITY · PI MOCCHETTI, ITALO · 2017 to 2018
$428k
NINDS NIH HHS NS079172NINDS NIH HHS R01 NS079172NINDS NIH HHS R21 NS104000NINDS NIH HHS R21 NS131097NINDS NIH HHS T32 NS121780
6 · The paper itself

Abstract

HIV-associated neurocognitive disorder (HAND) persists in people living with HIV (PLWH) despite antiretroviral therapy. HAND is characterized by synapto-dendritic damage, yet the cause of this pathology is still under investigation. Various viral proteins, including the envelope protein gp120, have been proposed to be the leading neurotoxic agents underlying HIV-mediated neuronal degeneration. Gp120 has been shown to bind to neuronal microtubules (MTs) and impair their functions. The dynamic properties of MTs are modulated by microtubule-associated proteins (MAP), including MAP2, which is particularly abundant in dendrites. This review article explores how gp120 could be altering the function of the neuronal cytoskeleton by affecting MAP2. These effects may serve as a causal link between viral proteins and HAND pathology.

Indexed as

AIDS Dementia ComplexHIV InfectionsMicrotubule-Associated ProteinsAnimalsHIV Envelope Protein gp120HumansMicrotubulesNeuronsHIV Envelope Protein gp120MAP2 protein, humanMicrotubule-Associated ProteinsGp120HANDHIVEMAP2Neuronal cytoskeletonNeurotoxicity

Identifiers

PMID40175790
PMCPMC13063158

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.