ReviewNature genetics2025
Psychiatric genetics in the diverse landscape of Latin American populations.
Abstract readReview
In one paragraph
Review in Nature genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 3 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Genomic Studies of Suicidal Thoughts and Behaviors in Latin American Populations: A Systematic Review.Biological psychiatry · 2026Pooled it
- A multi-cohort assessment of the polygenic prediction in ADHD treatment response.Psychiatry research · 2026Pooled it
- Genetic variation associated with depression in Latin American populations: a systematic review of single-nucleotide variants.Frontiers in psychiatry · 2026Pooled it
- Best practices for using biological data in psychological research.Journal of mood and anxiety disorders · 2026Review
- Considering social risk alongside genetic risk for bipolar disorder in the All of Us Research Program.HGG advances · 2026Article
- Transcriptomic characteristics of plasma from Chinese ethnic minority patients with major depressive disorder.Translational psychiatry · 2026Article
- Beyond DSM Categories: Criteria for Biologically Valid Disease Axes in Psychiatry.Journal of clinical medicine · 2026Review
- A comprehensive overview of the biological foundations of ADHD.Bioscience reports · 2026Review
- Functional Genomics Studies of Psychiatric Disorders in Individuals of Latin American Populations: A Scoping Review.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2026Article
- Pharmacogenes Associated with Suicidal Behavior: Addressing a Potential Therapeutic Window.Actas espanolas de psiquiatria · 2026Review
- Article
- Strategies in Global Ancestry and Local Ancestry Inference.Current protocols · 2026Article
- Exploratory RNA Sequencing Reveals Systemic Metabolic Dysregulation in Alzheimer's Disease: Insights from a Diverse Latin American Cohort.Molecular neurobiology · 2026Article
- Genomic landscape of autism spectrum disorder in Brazil.Genetics and molecular biology · 2026Article
- Computational whole-body-exposome models for global precision brain health.Nature communications · 2025Article
- Shared biological pathways linking ADHD and cortisol variability are related to externalizing behaviors.Psychoneuroendocrinology · 2025Article
- Genetic risk effects on psychiatric disorders act in sets.medRxiv : the preprint server for health sciences · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
83 authors.
Estela M Bruxel *Department of Translational Medicine, School of Medical Sciences, University of Campinas, Campinas, Brazil.
Diego L Rovaris *Department of Physiology and Biophysics, Instituto de Ciencias Biomedicas, Universidade de São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-8910-4927
Sintia I BelangeroDepartment of Morphology and Genetics, Universidade Federal de São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-2419-4351
Gabriela Chavarría-SoleyEscuela de Biología y Centro de Investigación en Biología Celular y Molecular, Universidad de Costa Rica, San Pedro, Costa Rica.
Alfredo B Cuellar-BarbozaDepartment of Psychiatry, School of Medicine, Universidad Autónoma de Nuevo León, San Nicolás de los Garza, México.
José J Martínez-MagañaDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Sheila T NagamatsuDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-4986-5094
Caroline M NievergeltDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-5766-8923
Diana L Núñez-RíosDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Vanessa K OtaDepartment of Morphology and Genetics, Universidade Federal de São Paulo, São Paulo, Brazil.
Roseann E PetersonDepartment of Psychiatry and Behavioral Sciences, Institute for Genomics in Health, State University of New York Downstate Health Sciences University, Brooklyn, NY, USA.ORCID http://orcid.org/0000-0001-6402-849X
Laura G SloofmanDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-7628-4378
Amy M AdamsDepartment of Psychiatry and Behavioral Sciences, Texas A&M University, College Station, TX, USA.ORCID http://orcid.org/0000-0002-8631-876X
Elinette AlbinoSchool of Health Professions, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico.
Angel T AlvaradoResearch Unit in Molecular Pharmacology and Genomic Medicine, VRI, San Ignacio de Loyola University, La Molina, Perú.
Diego Andrade-BritoDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-2054-4713
Paola Y Arguello-PascualliDepartment of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Cibele E BandeiraDepartment of Physiology and Biophysics, Instituto de Ciencias Biomedicas, Universidade de São Paulo, São Paulo, Brazil.
Claiton H D BauDepartment of Genetics, Institute of Biosciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.ORCID http://orcid.org/0000-0001-5644-3845
Cynthia M BulikDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0001-7772-3264
Joseph D BuxbaumDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-8898-8313
Carolina CappiDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Nadia S Corral-FriasDepartamento de Psicología, Universidad de Sonora, Hermosillo, México.
Alejo CorralesDepartamento de Psiquiatría, Universidad Nacional de Tucumán, San Miguel de Tucumán, Argentina.
Fabiana Corsi-ZuelliDepartment of Neuroscience, Ribeirão Preto Medical School, Universidade de São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0001-9202-3987
James J CrowleyDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0001-9051-1557
Renata B CupertinoDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-3452-0632
Bruna S da SilvaDepartment of Basic Health Sciences, Federal University of Health Sciences of Porto Alegre, Porto Alegre, Brazil.
Suzannah S De AlmeidaDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-5884-7461
Juan F De la HozPsychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-5584-7511
Diego A ForeroSchool of Health and Sport Sciences, Fundación Universitaria del Área Andina, Bogotá, Colombia.
Gabriel R FriesFaillace Department of Psychiatry and Behavioral Sciences, the University of Texas Health Science Center at Houston, Houston, TX, USA.
Joel GelernterDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-4067-1859
Yeimy González-GiraldoBiomedical Sciences Research Group, School of Medicine, Universidad Antonio Nariño, Bogotá, Colombia.
Eugenio H GrevetDepartment of Psychiatry and Legal Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Dorothy E GriceDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-8833-2549
Adriana Hernández-GarayuaDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
John M HettemaDepartment of Psychiatry and Behavioral Sciences, Texas A&M University, College Station, TX, USA.ORCID http://orcid.org/0000-0002-0105-9034
Agustín IbáñezLatin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.ORCID http://orcid.org/0000-0001-6758-5101
Iuliana Ionita-LazaDepartment of Biostatistics, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0002-9001-2026
Maria Claudia LattigDepartment of Biological Sciences, Universidad de los Andes, Bogotá, Colombia.
Yago C LimaDepartment of Physiology and Biophysics, Instituto de Ciencias Biomedicas, Universidade de São Paulo, São Paulo, Brazil.
Yi-Sian LinDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Sandra López-LeónQuantitative Safety Epidemiology, Novartis Pharma, East Hanover, NJ, USA.
Camila M LoureiroDepartment of Neuroscience, Ribeirão Preto Medical School, Universidade de São Paulo, São Paulo, Brazil.
Verónica Martínez-CerdeñoDepartment of Pathology, University of California Davis, Sacramento, CA, USA.
Gabriela A Martínez-LevyDepartment of Genetics, Subdirectorate of Clinical Research, National Institute of Psychiatry, México City, México.ORCID http://orcid.org/0000-0003-1736-5308
Kyle MelinSchool of Pharmacy, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico.ORCID http://orcid.org/0000-0002-4698-8021
Daniel Moreno-De-LucaPrecision Medicine in Autism Group, Division of Child and Adolescent Psychiatry, Department of Psychiatry, Faculty of Medicine and Dentistry, University of Alberta, Alberta Health Services, CASA Mental Health, Edmonton, Alberta, Canada.
Carolina Muniz CarvalhoDepartment of Psychiatry, Universidade Federal de São Paulo, São Paulo, Brazil.
Ana Maria OlivaresBroad Institute of Massachusetts Institute of Technology and Harvard University, Boston, MA, USA.
Victor F OliveiraDepartment of Physiology and Biophysics, Instituto de Ciencias Biomedicas, Universidade de São Paulo, São Paulo, Brazil.
Rafaella OrmondDisciplina de Biologia Molecular, Universidade Federal de São Paulo, São Paulo, Brazil.
Abraham A PalmerDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-3634-0747
Alana C PanzenhagenScience for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden.
Maria Rita Passos-BuenoDepartmento de Genetica e Biologia Evolutiva, Instituto de Biociências, Universidade de São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-9248-3008
Qian PengDepartment of Neuroscience, the Scripps Research Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-2662-3412
Eduardo Pérez-PalmaFacultad de Medicina Clínica Alemana, Centro de Genética y Genómica, Universidad del Desarrollo, Santiago, Chile.
Miguel L PrietoMental Health Service, Clínica Universidad de los Andes, Santiago, Chile.ORCID http://orcid.org/0000-0001-5578-4605
Panos RoussosCenter for Disease Neurogenomics, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-4640-6239
Sandra Sanchez-RoigeDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-6137-5699
Hernando Santamaría-GarcíaPhD Program of Neuroscience, Pontificia Universidad Javeriana, Hospital San Ignacio, Center for Memory and Cognition, Intellectus, Bogotá, Colombia.
Flávio M ShansisGraduate Program of Medical Sciences, Universidade do Vale do Taquari, Lajeado, Brazil.
Rachel R SharpNeuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0002-3070-9200
Eric A StorchDepartment of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA.
Maria Eduarda A TavaresDepartment of Genetics, Institute of Biosciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Grace E TietzDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Bianca A Torres-HernándezSchool of Pharmacy, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico.
Luciana Tovo-RodriguesPostgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.
Pilar TrellesDepartment of Psychiatry and Behavioral Sciences, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Eva M Trujillo-ChiVacuanResearch Department, Comenzar de Nuevo Eating Disorders Treatment Center, Monterrey, México.ORCID http://orcid.org/0000-0001-7419-3050
Maria M VelásquezInstituto de Genética Humana, Facultad de Medicina, Pontificia Universidad Javeriana, Bogotá, Colombia.ORCID http://orcid.org/0000-0001-7726-9620
Fernando Vera-UrbinaSchool of Pharmacy, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico.
Georgios VoloudakisCenter for Disease Neurogenomics, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-5729-632X
Talia Wegman-OstroskyPrecision Medicine, Instituto Nacional de Cancerología, México City, México.ORCID http://orcid.org/0000-0002-3207-6697
Jenny Zhen-DuanDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA.
Hang ZhouDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-7694-6391
Latin American Genomics Consortium
Marcos L SantoroDisciplina de Biologia Molecular, Universidade Federal de São Paulo, São Paulo, Brazil.
Humberto NicoliniLaboratorio de Enfermedades Psiquiátricas, Neurodegenerativas y Adicciones, Instituto Nacional de Medicina Genómica, Mexico City, México.
Elizabeth G AtkinsonDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA. Elizabeth.Atkinson@bcm.edu.ORCID http://orcid.org/0000-0002-6308-776X
Paola Giusti-RodríguezDepartment of Psychiatry, University of Florida College of Medicine, Gainesville, FL, USA. giustirodriguezp@ufl.edu.ORCID http://orcid.org/0000-0002-1921-1305
Janitza L Montalvo-OrtizDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA. janitza.montalvo-ortiz@yale.edu.ORCID http://orcid.org/0000-0002-7657-8365
Funding
Eating Disorders Genetics Initiative (EDGI)R01MH120170 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BULIK, CYNTHIA M · 2019 to 2023
$7.2MAn automated machine learning approach to language changes in Alzheimer’s disease and frontotemporal dementia across Latino and English-speaking populationsR01AG075775 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI, Adolfo Martin Garcia · 2023 to 2026
$7.2MLatino Ancestry Genomic Psychiatry CohortR01MH123451 · NIMH · SUNY DOWNSTATE MEDICAL CENTER · PI BIGDELI, TIM BERNARD, FANOUS, AYMAN H · 2020 to 2025
$7.1MUS-South American Initiative for Genetic-Neural-Behavioral Interactions in Human Neurodegenerative ResearchR01AG057234 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Claudia Duran-Aniotz, Agustin M. Ibanez · 2019 to 2026
$6.1MInterdisciplinary Research Fellowship in NeuroAIDSR25MH081482 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MARIANA CHERNER · 2007 to 2026
$5.2M1/3 Eating Disorders Genetics Initiative 2 (EDGI2)R01MH136149 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CYNTHIA M BULIK, Laura Marianne Huckins · 2024 to 2026
$5.1MCross-Population Working Group on Genes and Environment in Major Depression (POP-GEM): Advancing the Understating of Etiology through DiversityR01MH125938 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI Roseann Elizabeth Peterson · 2022 to 2026
$4.2MPredicting the multi-omic impact of psychiatric GWAS associationsR01MH118278 · NIMH · YALE UNIVERSITY · PI HUCKINS, LAURA MARIANNE · 2019 to 2023
$3.6M1/7 PGC: Advancing Discovery and ImpactR01MH124871 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BULIK, CYNTHIA M, SULLIVAN, PATRICK F · 2021 to 2025
$3.5M7/7 Psychiatric Genomics Consortium: Advancing Discovery and ImpactR01DA054869 · NIDA · WASHINGTON UNIVERSITY · PI AGRAWAL, ARPANA, EDENBERG, HOWARD J · 2021 to 2025
$3.3MA Framework for Translating Polygenic Findings Related to Alcohol Use Disorder Across SpeciesR01AA029688 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Hae Kyung Im, Abraham A Palmer · 2022 to 2026
$3.1MEmpowering gene discovery and accelerating clinical translation for diverse admixed populationsR01HG012869 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI Elizabeth Grace Atkinson · 2023 to 2026
$3.1MNational Science Foundation (NSF) 2023351083NHGRI NIH HHS R01 HG012869NIA NIH HHS R01 AG057234NIA NIH HHS R01 AG075775NIDA NIH HHS DP1 DA054373NIDA NIH HHS DP1 DA054394NIDA NIH HHS R01 DA054869NIDA NIH HHS T32 DA053558NIMH NIH HHS K01 MH121580NIMH NIH HHS R01 MH118278NIMH NIH HHS R01 MH119084NIMH NIH HHS R01 MH120170NIMH NIH HHS R01 MH123451NIMH NIH HHS R01 MH124871NIMH NIH HHS R01 MH125938NIMH NIH HHS R01 MH131013NIMH NIH HHS R01 MH134039NIMH NIH HHS R01 MH136149NIMH NIH HHS R25 MH081482NIMH NIH HHS R56 MH129437NIMH NIH HHS U01 MH109528NIMH NIH HHS U01 MH125050NIMH NIH HHS U01 MH125062U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (NHGRI) R01HG012869U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) 5R25MH081482-17U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH125938U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH131013U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH136149;R01MH134039,R56MH129437; R01MH120170; R01MH124871; R01MH119084; R01MH118278; R01MH124871U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) U01MH125050U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) U01MH125062U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA) R01AA029688U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) 1DP1DA058737-01U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) 5R01DA054869U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) DP1DA054394Vetenskapsrådet (Swedish Research Council) 538-2013-8864
Abstract
Psychiatric disorders are highly heritable and polygenic, influenced by environmental factors and often comorbid. Large-scale genome-wide association studies (GWASs) through consortium efforts have identified genetic risk loci and revealed the underlying biology of psychiatric disorders and traits. However, over 85% of psychiatric GWAS participants are of European ancestry, limiting the applicability of these findings to non-European populations. Latin America and the Caribbean, regions marked by diverse genetic admixture, distinct environments and healthcare disparities, remain critically understudied in psychiatric genomics. This threatens access to precision psychiatry, where diversity is crucial for innovation and equity. This Review evaluates the current state and advancements in psychiatric genomics within Latin America and the Caribbean, discusses the prevalence and burden of psychiatric disorders, explores contributions to psychiatric GWASs from these regions and highlights methods that account for genetic diversity. We also identify existing gaps and challenges and propose recommendations to promote equity in psychiatric genomics.
Indexed as
Mental DisordersCaribbean RegionGenetic Predisposition to DiseaseGenetic VariationGenome-Wide Association StudyGenomicsHumansLatin America
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.