ArticleJournal of perinatology : official journal of the California Perinatal Association2025
Effect of therapeutic hypothermia on surfactant proteins, anti-inflammatory and pro-fibrotic mediators.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
objectivesTo study the effect of hypothermia on surfactant proteins, anti-inflammatory and pro-fibrotic mediators
designProspective, pragmatic study enrolling asphyxiated neonates without lung injury. Surfactant proteins (SP), Club cell secretory protein (CC-10), tumor growth factor-β1 (TGF-β1), human fibroblast growth factor-2 (hFGF) and anti-inflammatory interleukins (IL) were measured in broncho-alveolar lavage fluids obtained before, during and after hypothermia.
resultsTwelve neonates were studied. SP-A, -B, -C, -D and CC-10 levels were similar before, during and after hypothermia. IL-10, IL-13, IL-14 were inconsistently detected only in five out of twelve patients and not in all timepoints; TGF-β1 was always undetectable. hFGF decreased during hypothermia (pre = 92 [52-193.6], during = 19.4 [0-42.6], post = 31.8 [0-83] ng/mL, p = 0.026) with levels before hypothermia being significantly higher than those obtained during and after the treatment (post hoc p = 0.025).
conclusionsIn cooled neonates without any lung disorder, hypothermia is associated with lower hFGF but not with any changes in surfactant proteins or anti-inflammatory molecules.
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