ArticleCommunications biology2025
Power-law adaptation in the presynaptic vesicle cycle.
Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Direct energy consumption by inhibitory GABAFrontiers in neuroscience · 2026Article
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5 authors.
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Abstract
After synaptic transmission, fused synaptic vesicles are recycled, enabling the synapse to recover its capacity for renewed release. The recovery steps, which range from endocytosis to vesicle docking and priming, have been studied individually, but it is not clear what their impact on the overall dynamics of synaptic recycling is, and how they influence signal transmission. Here we model the dynamics of vesicle recycling and find that the multiple timescales of the recycling steps are reflected in synaptic recovery. This leads to multi-timescale synapse dynamics, which can be described by a simplified synaptic model with 'power-law' adaptation. Using cultured hippocampal neurons, we test this model experimentally, and show that the duration of synaptic exhaustion changes the effective synaptic recovery timescale, as predicted by the model. Finally, we show that this adaptation could implement a specific function in the hippocampus, namely enabling efficient communication between neurons through the temporal whitening of hippocampal spike trains.
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