Evidence map›Paper›PMID 40175637›Full record

Observational studyJournal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology2025

Double plating versus nail-plate construct in AO 33C distal femur fractures: treatment choice affects knee alignment, clinical outcomes, and quality of life-a multicenter study.

Domenico De Mauro, Amarildo Smakaj, Alessandro Casiraghi, Claudio Galante, Federico Bove, Mario Arduini, Giovanni Vicenti, Francesco Addevico, Abramo Fratus, Nicola Macellari and 5 more

Abstract readMulticenter StudyObservational StudyComparative Study
In one paragraph

Observational study in Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Outcomes of Periprosthetic Distal Femur Fractures by Fixation Construct: A Retrospective Cohort Study.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026
    Article
  3. Article
  4. [Value of retrograde femoral nailing : Pros and cons].Unfallchirurgie (Heidelberg, Germany) · 2025
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Domenico De MauroDepartment of Orthopedics, Ageing and Rheumatological Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168, Rome, Italy.
Amarildo SmakajDepartment of Orthopedics and Geriatrics Sciences, Università Cattolica del Sacro Cuore, Largo Francesco Vito, 8, 00168, Rome, Italy.
Alessandro CasiraghiOrthopedics and Traumatology Unit, ASST Degli Spedali Civili, 25123, Brescia, Italy.
Claudio GalanteOrthopedics and Traumatology Unit, ASST Degli Spedali Civili, 25123, Brescia, Italy.
Federico BoveOrthopedics and Traumatology Unit, ASST Grande Ospedale Metropolitano Niguarda, 20162, Milan, Italy.
Mario ArduiniOrthopedics and Traumatology Unit, Ospedale Sant'Eugenio, 00144, Rome, Italy.
Giovanni VicentiDepartment of Basic Medical Sciences, Neuroscience and Sense Organs, School of Medicine, Aldo Moro University, 70121, Bari, Italy.
Francesco AddevicoOrthopedics and Traumatology Unit, ASST Grande Ospedale Metropolitano Niguarda, 20162, Milan, Italy.
Abramo FratusOrthopedics and Traumatology Unit, ASST Degli Spedali Civili, 25123, Brescia, Italy.
Nicola MacellariDepartment of Orthopedics and Geriatrics Sciences, Università Cattolica del Sacro Cuore, Largo Francesco Vito, 8, 00168, Rome, Italy.
Matteo CareddaDepartment of Orthopedics and Geriatrics Sciences, Università Cattolica del Sacro Cuore, Largo Francesco Vito, 8, 00168, Rome, Italy.
Claudio BuonoDepartment of Basic Medical Sciences, Neuroscience and Sense Organs, School of Medicine, Aldo Moro University, 70121, Bari, Italy.
Giulio MaccauroDepartment of Orthopedics, Ageing and Rheumatological Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168, Rome, Italy.
Giuseppe RovereDepartment of Orthopedics and Geriatrics Sciences, Università Cattolica del Sacro Cuore, Largo Francesco Vito, 8, 00168, Rome, Italy. giuseppe.rovere02@icatt.it.
Francesco LiuzzaDepartment of Orthopedics, Ageing and Rheumatological Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDistal femur fractures present a significant challenge for orthopedic surgeons, accounting for approximately 5% of all femoral fractures. Among the most commonly reported combined techniques in the literature are the double-plate technique and the retrograde nailing plus lateral plating, the nail-plate construct (NPC). The aim of our study is to compare surgical data, quality of life, and functional outcomes in 33-C fractures treated with either double-plate constructs or a retrograde nailing plus lateral plate. MATERIALS AND

methodsA multicenter retrospective observational study was conducted in accordance with Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines. Diagnoses were made on the basis of the AO classification, utilizing traditional radiological assessments. Patients were categorized into two groups on the basis of the surgical treatment they received: The NPC group comprised patients who underwent surgery with nail-plate construct, while the Plate group consisted of those who had surgery with double plating.

resultsA total of 42 patients were included in the study. The NPC group comprised 26 patients with a mean age of 58.4 ± 18.8 years, while the Plate group consisted of 16 patients with a mean age of 61.3 ± 16.4 years. Significant differences were observed in knee extension recovery (p = 0.010) and lateral distal femur angle (LDFA) (p < 0.001). Linear regression showed a significant influence from treatment choice on all the Knee Injury and Osteoarthritis Outcome Score (KOOS) subscales, as well as in all domains of the European Quality of Life Five Dimensions Five-Level Version (EQ-5D-5L), except for the Daily Self-Care domain.

conclusionsNail-plate constructs seems to lead to significantly better outcomes in AO type C distal femur fractures, compared with double plating, in terms of knee function and quality of life. Significant differences are shown also in anatomical outcomes, especially in extension gap, and LDFA. LEVEL OF EVIDENCE: III.

Indexed as

Bone NailsBone PlatesFemoral FracturesFracture Fixation, InternalFracture Fixation, IntramedullaryQuality of LifeAdultAgedFemaleFemoral Fractures, DistalHumansKnee JointMaleMiddle AgedRetrospective StudiesTreatment OutcomeComplicationsDistal femur fracturesDouble platesKnee fracturesPlate and nail

Identifiers

PMID40175637
PMCPMC11965052

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.