Evidence map›Paper›PMID 40175568›Full record

ArticleScientific reports2025

Atomic-level investigation of KCNJ2 mutations associated with ventricular arrhythmic syndrome phenotypes.

Saba Munawar, Corey L Anderson, Louise Reilly, Ryan Woltz, Yusra Sajid Kiani, Nipavan Chiamvimonvat, Lee L Eckhardt

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Saba MunawarCellular and Molecular Arrhythmia Research Program, Department of Medicine, University of Wisconsin- Madison School of Medicine and Public Health, Madison, USA.
Corey L AndersonCellular and Molecular Arrhythmia Research Program, Department of Medicine, University of Wisconsin- Madison School of Medicine and Public Health, Madison, USA.
Louise ReillyCellular and Molecular Arrhythmia Research Program, Department of Medicine, University of Wisconsin- Madison School of Medicine and Public Health, Madison, USA.
Ryan WoltzDivision of Cardiovascular Medicine, Department of Internal Medicine, School of Medicine, University of California, Davis, Davis, CA, USA.
Yusra Sajid KianiSchool of Interdisciplinary Engineering and Sciences, NUST, Islamabad, Pakistan.
Nipavan ChiamvimonvatDivision of Cardiovascular Medicine, Department of Internal Medicine, School of Medicine, University of California, Davis, Davis, CA, USA.
Lee L EckhardtCellular and Molecular Arrhythmia Research Program, Department of Medicine, University of Wisconsin- Madison School of Medicine and Public Health, Madison, USA. lle@medicine.wisc.edu.

Funding

Multiomics and Functional Characterization Establish Druggable Targets for PVC-Driven Idiopathic VFR01HL170521 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Lee Lochbaum Eckhardt, Eleonora Grandi · 2023 to 2026
$3.1M
Deep Mutational Scanning and Functional Analysis of Repolarization DeterminantsR01HL163987 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI ECKHARDT, LEE LOCHBAUM · 2022 to 2025
$1.6M
National Institute of Health NIH R01 HL163987NHLBI NIH HHS R01 HL163987NHLBI NIH HHS R01 HL170521NIH HHS NIH R01 HL170521
6 · The paper itself

Abstract

KCNJ2 encodes the inward rectifying potassium channel (Kir2.1) that underlies I

Indexed as

Andersen SyndromeArrhythmias, CardiacMutationPotassium Channels, Inwardly RectifyingFemaleHumansMaleMolecular Dynamics SimulationPhenotypeKCNJ2 protein, humanPotassium Channels, Inwardly RectifyingInward rectifier currentKCNJ2Kir2.1MD simulationMolecular modelingNormal mode analysisPCASite-directed mutagenesis analysis

Identifiers

PMID40175568
PMCPMC11965533

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.