ArticleNature2025
Psilocybin's lasting action requires pyramidal cell types and 5-HT
Erratum issuedAbstract read
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 58 papers.
0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed.
- Serotonin biology as a basis for explaining psychedelic drug action.Current biology : CB · 2026Review
- Deconstruction of lysergic acid diethylamide.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Prior trauma shapes the effects of psilocybin on stress sensitization in mice.Neuroscience letters · 2026Article
- A circuit dissection of perception-action decoupling in S-ketamine-induced hallucination-like states.Molecular psychiatry · 2026Article
- Mechanistic Basis for 5-HTNature communications · 2026Article
- Psilocybin enhances sociability only in altered behavioural state and does not need an awake experience to be effective.Nature communications · 2026Article
- Natural Products as GPCR-Targeting Antidepressant Candidates: Advances and Opportunities.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Role of β-Arrestin2 Signaling in Neuropharmacological Effects of Psychedelic Drugs.ACS chemical neuroscience · 2026Article
- Psychedelics align brain activity with context.Nature · 2026Article
- Long- term administration of low doses of psilocybin causes epigenetic changes in the rat medial prefrontal cortex.Psychopharmacology · 2026Article
- Psilocybin restores behavior and 5-HTCell reports. Medicine · 2026Article
- Psychedelic drug action at dendrites is gated by behavioral state and serotonin receptors.bioRxiv : the preprint server for biology · 2026Article
- Topographically organized dorsal raphe activity modulates forebrain sensory-motor representations and contributes to defensive behaviors.Nature communications · 2026Article
- Psychedelics produce enduring enhancement of reward responsiveness in male rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Psilocybin selectively rescues cognitive flexibility impairments caused by aberrant prefrontal error signaling.bioRxiv : the preprint server for biology · 2026Article
- Dissociating the Hallucinogenic and Neuroplastic Effects of Psilocybin.bioRxiv : the preprint server for biology · 2026Article
- The working lives of neuronal 5-HTRSC chemical biology · 2026Review
- Complementary roles of cell-type-specific plasticity in shaping neocortical dynamics for learning action timing.Nature communications · 2026Article
- The Emerging Neurobiology of Psychedelics: Critical Periods, Metaplasticity, and Extracellular Matrix Remodeling.Annual review of neuroscience · 2026Review
- Psychedelics in treatment-resistant depression: a comprehensive review of mechanisms, clinical evidence, and recommendations.Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater · 2026Review
Corrections and comments
- Erratum issued
- Update of
Authors and funding
14 authors.
Ling-Xiao Shao *Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.ORCID 0009-0006-9503-1230
Clara Liao *Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
Pasha A DavoudianMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.ORCID 0000-0002-5096-7610
Neil K SavaliaMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
Quan JiangMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
Cassandra WojtasiewiczMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
Diran TanMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
Jack D NothnagelMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
Rong-Jian LiuDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Samuel C WoodburnMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
Olesia M BilashMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
Hail KimGraduate School of Medical Science and Engineering, KAIST, Daejeon, Republic of Korea.ORCID 0000-0002-6652-1349
Alicia CheDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-7530-8531
Alex C KwanMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA. alex.kwan@cornell.edu.ORCID 0000-0003-2169-1667
Funding
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007205 · NIGMS · YALE UNIVERSITY · PI KAZMIERCZAK, BARBARA I · 1985 to 2019
$42.9MInterdepartmental Neuroscience Program (INP)T32NS041228 · NINDS · YALE UNIVERSITY · PI Charles A Greer, Marina R Picciotto · 2001 to 2026
$12.0MTRAINING IN THE PATHOGENESIS OF INFECTIOUS DISEASEST32AI007517 · NIAID · YALE UNIVERSITY · PI Jaimie Meyer, Albert C Shaw · 1997 to 2026
$6.1MCellular basis of psilocybin actions in frontal cortexR01MH128217 · NIMH · CORNELL UNIVERSITY · PI CHUN-HAY ALEX KWAN · 2022 to 2026
$2.9MA Dendritic Substrate for Fast-Acting Antidepressant ActionR01MH121848 · NIMH · YALE UNIVERSITY · PI KWAN, CHUN-HAY ALEX · 2020 to 2024
$2.6MDeep and Fast Imaging Using Adaptive Excitation SourcesU01NS128660 · NINDS · CORNELL UNIVERSITY · PI XU, CHRIS · 2022 to 2025
$2.4MRole of cortical GABAergic interneurons in psychedelic drug actionR01MH137047 · NIMH · CORNELL UNIVERSITY · PI CHUN-HAY ALEX KWAN · 2024 to 2026
$1.9MNeural Mechanisms Linking Sensory Perception and Social BehaviorR01NS133434 · NINDS · YALE UNIVERSITY · PI Alicia Yue Che · 2023 to 2026
$1.6MEffects of Early-life Cannabinoid Exposure on Prefrontal Circuitry and Cognitive Behavior across DevelopmentR01DA059378 · NIDA · YALE UNIVERSITY · PI Alicia Yue Che · 2024 to 2026
$1.5MMaturation of Somatosensory Circuits for Social BehaviorsR00NS114166 · NINDS · YALE UNIVERSITY · PI CHE, ALICIA YUE · 2022 to 2024
$740kZeiss LSM710 Confocal Microscope for Shared Imaging FacilityS10RR025502 · NCRR · CORNELL UNIVERSITY · PI WILLIAMS, REBECCA M · 2009 to 2009
$500kAcquisition of an automated phase and fluorescence microscope for Cornell BRC Imaging FacilityS10OD032251 · OD · CORNELL UNIVERSITY · PI WILLIAMS, REBECCA M · 2022 to 2022
$229kNCRR NIH HHS S10 RR025502NIAID NIH HHS T32 AI007517NIDA NIH HHS F30 DA059437NIDA NIH HHS R01 DA059378NIGMS NIH HHS T32 GM007205NIH HHS S10 OD032251NIMH NIH HHS F30 MH129085NIMH NIH HHS R01 MH121848NIMH NIH HHS R01 MH128217NIMH NIH HHS R01 MH137047NINDS NIH HHS R00 NS114166NINDS NIH HHS R01 NS133434NINDS NIH HHS T32 NS041228NINDS NIH HHS U01 NS128660
Abstract
Psilocybin is a serotonergic psychedelic with therapeutic potential for treating mental illnesses
Indexed as
HallucinogensPsilocybinPyramidal CellsReceptor, Serotonin, 5-HT2AAction PotentialsAnimalsCalciumDendritic SpinesFemaleFrontal LobeMaleMiceMice, Inbred C57BLNeuronal PlasticityCalciumHallucinogensPsilocybinReceptor, Serotonin, 5-HT2A
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.