ArticleNature2025
The RAD52 double-ring remodels replication forks restricting fork reversal.
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In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- CHK2 regulates MUS81-dependent DSBs in response to replication stress and BRCA2 deficiency.Nucleic acids research · 2026Article
- Mechanism of single-strand annealing from native mass spectrometry and cryo-EM structures of RAD52 homolog Mgm101.Nucleic acids research · 2026Article
- The human RAD52 complex undergoes phase separation and facilitates bundling and end-to-end tethering of RAD51 presynaptic filaments.Nucleic acids research · 2026Article
- Dynamic Assemblies in Genome Maintenance.Advances in experimental medicine and biology · 2026Review
- Mechanism of single-strand annealing from native mass spectrometry and cryo-EM structures of RAD52 homolog Mgm101.bioRxiv : the preprint server for biology · 2025Article
- S-phase checkpoint protects from aberrant replication fork processing and degradation.Nucleic acids research · 2025Article
- The human RAD52 complex undergoes phase separation and facilitates bundling and end-to-end tethering of RAD51 presynaptic filaments.bioRxiv : the preprint server for biology · 2024Article
- CRISPR knockout genome-wide screens identify the HELQ-RAD52 axis in regulating the repair of cisplatin-induced single-stranded DNA gaps.Nucleic acids research · 2024Article
- CRISPR knockout genome-wide screens identify the HELQ-RAD52 axis in regulating the repair of cisplatin-induced single stranded DNA gaps.bioRxiv : the preprint server for biology · 2024Article
Corrections and comments
- Update of
Authors and funding
15 authors.
Masayoshi Honda *Department of Biochemistry and Molecular Biology, University of Iowa Carver College of Medicine, Iowa City, IA, USA.ORCID 0000-0001-8920-6301
Mortezaali Razzaghi *Department of Biochemistry and Molecular Biology, University of Iowa Carver College of Medicine, Iowa City, IA, USA.ORCID 0000-0002-5048-3624
Paras GaurDepartment of Biochemistry and Molecular Biology, University of Iowa Carver College of Medicine, Iowa City, IA, USA.ORCID 0000-0002-2112-389X
Eva MalacariaMechanisms, Biomarkers and Models section, Department of Environment and Health, Istituto Superiore di Sanità, Rome, Italy.
Giorgia MarozziMechanisms, Biomarkers and Models section, Department of Environment and Health, Istituto Superiore di Sanità, Rome, Italy.
Ludovica Di BiagiMechanisms, Biomarkers and Models section, Department of Environment and Health, Istituto Superiore di Sanità, Rome, Italy.
Francesca Antonella AielloMechanisms, Biomarkers and Models section, Department of Environment and Health, Istituto Superiore di Sanità, Rome, Italy.ORCID 0000-0003-3013-4504
Emeleeta A PaintsilDepartment of Biochemistry and Molecular Biology, University of Iowa Carver College of Medicine, Iowa City, IA, USA.ORCID 0000-0003-2110-0652
Andrew J StanfieldDepartment of Biochemistry and Molecular Biology, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
Bailey J DeppeDepartment of Biochemistry and Molecular Biology, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
Lokesh GakharDepartment of Biochemistry and Molecular Biology, University of Iowa Carver College of Medicine, Iowa City, IA, USA.ORCID 0000-0002-3319-1902
Nicholas J SchnickerProtein and Crystallography Facility, University of Iowa, Iowa City, IA, USA.ORCID 0000-0002-5189-4943
M Ashley SpiesDivision of Medicinal and Natural Products Chemistry, Department of Pharmaceutical Sciences and Experimental Therapeutics, University of Iowa, Iowa City, IA, USA.ORCID 0000-0002-1248-5362
Pietro PichierriMechanisms, Biomarkers and Models section, Department of Environment and Health, Istituto Superiore di Sanità, Rome, Italy.ORCID 0000-0002-2702-3523
Maria SpiesDepartment of Biochemistry and Molecular Biology, University of Iowa Carver College of Medicine, Iowa City, IA, USA. maria-spies@uiowa.edu.ORCID 0000-0002-7375-8037
Funding
Pacific Northwest Center for Cryo-EM - Screening supplementU24GM129547 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI EVANS, JAMES E, GOUAUX, JAMES E · 2018 to 2023
$54.8MNCCAT: National Center for CryoEM Access and Training- Supplement for Windows 10 and FFIU24GM129539 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2018 to 2023
$53.9MNCCAT: National Center for CryoEM Access and TrainingR24GM154192 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI EDWARD T ENG, Jeffrey S Kieft · 2024 to 2026
$21.0MTRAINING PROGRAM IN FREE RADICAL AND RADIATION BIOLOGYT32CA078586 · NCI · UNIVERSITY OF IOWA · PI SPITZ, DOUGLAS ROBERT · 1999 to 2024
$5.7MThe Role of Human RAD52 Protein in Genome StabilityR01CA232425 · NCI · UNIVERSITY OF IOWA · PI Maria Spies · 2019 to 2026
$3.1MNCI NIH HHS R01 CA232425NCI NIH HHS T32 CA078586NIGMS NIH HHS R24 GM154192NIGMS NIH HHS U24 GM129539NIGMS NIH HHS U24 GM129547
Abstract
Human RAD52 is a multifunctional DNA repair protein involved in several cellular events that support genome stability, including protection of stalled DNA replication forks from excessive degradation
Indexed as
DNA ReplicationRad52 DNA Repair and Recombination ProteinCryoelectron MicroscopyDNA HelicasesDNA, Single-StrandedHumansKineticsModels, MolecularNucleoproteinsReplication Protein ASingle Molecule ImagingDNA HelicasesDNA, Single-StrandedNucleoproteinsRad52 DNA Repair and Recombination ProteinRAD52 protein, humanReplication Protein ASMARCAL1 protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.