ArticleNature2025
Clinically relevant clot resolution via a thromboinflammation-on-a-chip.
Abstract read
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Heart-on-a-chip and vasculature-on-a-chip platforms as models of cardiovascular disease.Nature reviews. Cardiology · 2026Review
- Microfluidic Platforms for Modeling Cancer-Associated Thrombosis: Current Status and Future Directions.Research and practice in thrombosis and haemostasis · 2026Review
- Dual RONS-responsive chemiluminescence-guided multimodal thrombolysis based on an aggregation-induced emission cobalt-porphyrin nanoplatform.Chemical science · 2026Article
- Biomimetic flowing vessel-on-a-chip recruiting glycocalyx features for investigating dexmedetomidine function.Materials today. Bio · 2026Article
- Investigational New Drug-enabling studies in a human vessel-chip: Are we there yet?Bioengineering & translational medicine · 2026Review
- Advanced technologies of artery-on-a-chip: a review of construction strategies and disease models.Angiogenesis · 2026Review
- Article
- Engineering design of platelet-mimicking therapeutic systems: multilevel biomimicry, gating strategies, and translational boundaries.Frontiers in bioengineering and biotechnology · 2026Review
- Microfluidic Chip Platforms for Red Blood Cell Storage Lesion Quality Control and Precision Transfusion.Research (Washington, D.C.) · 2026Review
- Time and architecture: the next two dimensions of microphysiological systems.npj biomedical innovations · 2026Review
- An Ex Vivo Patient-Derived Tumor-Bearing Human Kidney Model Recapitulates Drug Toxicity and Metabolic Distribution.Research (Washington, D.C.) · 2026Article
- Endo-chip laser-induced thrombus formation: a vessel-on-chip model for in vitro testing of antithrombotic agents.Blood vessels, thrombosis & hemostasis · 2025Article
- Microfluidic organ-on-a-chip for modeling coronary artery disease: Recent applications, limitations and potential.Journal of tissue engineeringReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Yongzhi QiuThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA, USA. yongzhi.qiu@emory.edu.ORCID 0000-0002-3837-824X
Jessica LinThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA, USA.ORCID 0000-0002-9653-9160
Audrey WangThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA, USA.
Zhou FangThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA, USA.
Yumiko SakuraiThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA, USA.
Hyoann ChoiThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA, USA.ORCID 0000-0001-7974-1570
Evelyn K WilliamsThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA, USA.
Elaissa T HardyThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA, USA.
Kristin MaherDivision of Hematology, Oncology, Bone Marrow Transplant, and Cellular Therapy, Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA.ORCID 0000-0002-7263-8789
Ahmet F CoskunThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA, USA.ORCID 0000-0002-5797-1524
Gary WoodsDepartment of Pediatrics, Division of Pediatric Hematology/Oncology, Aflac Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA, USA.
Wilbur A LamThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA, USA. wilbur.lam@emory.edu.ORCID 0000-0002-0325-7990
Funding
Unraveling the immune response to factor VIIIU54HL141981 · NHLBI · EMORY UNIVERSITY · PI MEEKS, SHANNON L. · 2018 to 2022
$8.1MEngineering biophysical microtechnologies for hematologic applications in health and diseaseR35HL145000 · NHLBI · EMORY UNIVERSITY · PI LAM, WILBUR A · 2019 to 2025
$5.0MAtlanta Network for Training In KUH Scientific Research (ATLANTIS)TL1DK136047 · NIDDK · EMORY UNIVERSITY · PI Vivien Andrea Sheehan · 2022 to 2026
$3.0MRedefining Clinical Viscosity in Sickle Cell Diseaseby Leveraging Microfluidic TechnologiesR01HL140589 · NHLBI · EMORY UNIVERSITY · PI LAM, WILBUR A, WOOD, DAVID KEVIN · 2018 to 2021
$3.0MPlatelet-like particles for augmenting hemostasisR01HL130918 · NHLBI · UNIVERSITY OF VIRGINIA · PI BARKER, THOMAS HARRISON, LAM, WILBUR A · 2016 to 2019
$2.7MComplement in the Pathogenesis of Acute Chest SyndromeR01HL163637 · NHLBI · EMORY UNIVERSITY · PI Satheesh Chonat · 2024 to 2026
$2.1MModeling atypical hemolytic uremic syndrome with hydrogel-based microvasculature-on-chip technologiesR21EB028519 · NIBIB · EMORY UNIVERSITY · PI CHONAT, SATHEESH, QIU, YONGZHI · 2019 to 2021
$639kNHLBI NIH HHS R01 HL130918NHLBI NIH HHS R01 HL140589NHLBI NIH HHS R01 HL163637NHLBI NIH HHS R35 HL145000NHLBI NIH HHS U54 HL141981NIBIB NIH HHS R21 EB028519NIDDK NIH HHS TL1 DK136047
Abstract
Thromboinflammation occurs in various diseases, leading to life-threatening microvascular occlusion with resulting end-organ failure
Indexed as
Blood CoagulationLab-On-A-Chip DevicesThromboinflammationThrombosisAnemia, Sickle CellAnimalsFemaleFibrinolysisFibrinolytic AgentsHumansHydrogelsLeukocyte ElastaseMaleMiceMicrovesselsTime FactorsFibrinolytic AgentsHydrogelsLeukocyte ElastaseTissue Plasminogen Activator
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.