Evidence map›Paper›PMID 40175547›Full record

ArticleNature2025

A neural mechanism for learning from delayed postingestive feedback.

Christopher A Zimmerman, Scott S Bolkan, Alejandro Pan-Vazquez, Bichan Wu, Emma F Keppler, Jordan B Meares-Garcia, Eartha Mae Guthman, Robert N Fetcho, Brenna McMannon, Junuk Lee and 8 more

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Lasting aversive consequences of a single dose of 4-hydroxytamoxifen.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. Maternal experience alters brain-wide representation of infant cries.bioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Article
  8. A lateralized pathway for associating nutrients with flavors.bioRxiv : the preprint server for biology · 2025
    Article
  9. Article
  10. Ingestion-activated CGRP neurons control learning but not satiety.bioRxiv : the preprint server for biology · 2025
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Neural pathways of nausea and roles in energy balance.Current opinion in neurobiology · 2025
    Review
  17. The gut and heart's role in reward processing.Frontiers in integrative neuroscience · 2025
    Review
  18. Article
  19. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Christopher A ZimmermanPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA. czimmerman@princeton.edu.ORCID 0000-0002-6286-1485
Scott S BolkanPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Alejandro Pan-VazquezPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Bichan WuPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Emma F KepplerPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.ORCID 0009-0001-8501-1985
Jordan B Meares-GarciaPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.ORCID 0009-0005-6203-899X
Eartha Mae GuthmanPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Robert N FetchoPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Brenna McMannonPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Junuk LeePrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Austin T HoagPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Laura A LynchPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Sanjeev R JanarthananPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Juan F López LunaPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.ORCID 0009-0004-2558-7618
Adrian G BondyPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Annegret L FalknerPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.ORCID 0000-0001-9756-7887
Samuel S-H WangPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.ORCID 0000-0002-0490-9786
Ilana B WittenPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA. iwitten@princeton.edu.ORCID 0000-0003-0548-2160

Funding

P5: Mechanistic Multi-Region Brain ModelsU19NS132720 · NINDS · PRINCETON UNIVERSITY · PI Carlos D Brody, Ila R. Fiete · 2023 to 2026
$21.5M
State-dependent Decision-making in Brainwide Neural CircuitsU19NS123716 · NINDS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI PANINSKI, LIAM M · 2021 to 2025
$18.2M
Subcortical Neural Coding and DynamicsU19NS104648 · NINDS · PRINCETON UNIVERSITY · PI SEUNG, HYUNJUNE SEBASTIAN · 2017 to 2021
$15.3M
Project 4: Neural mechanisms underlying latent-cause inferenceP50MH136296 · NIMH · PRINCETON UNIVERSITY · PI DAVID HAROLD ZALD · 2024 to 2026
$12.9M
Individual differences through self-reinforcement of suboptimal strategiesDP1MH136573 · NIMH · PRINCETON UNIVERSITY · PI Ilana Witten · 2023 to 2026
$5.7M
A web-based framework for multi-modal visualization and annotation of neuroanatomical dataRF1MH128776 · NIMH · PRINCETON UNIVERSITY · PI KLEINFELD, DAVID, WANG, SAMUEL SHENG-HUNG · 2021 to 2021
$1.6M
Cross-region neural mechanisms that support conditioned taste aversionK99DA059957 · NIDA · PRINCETON UNIVERSITY · PI ZIMMERMAN, CHRISTOPHER · 2024 to 2025
$312k
NIDA NIH HHS K99 DA059957NIMH NIH HHS DP1 MH136573NIMH NIH HHS P50 MH136296NIMH NIH HHS RF1 MH128776NINDS NIH HHS U19 NS104648NINDS NIH HHS U19 NS123716NINDS NIH HHS U19 NS132720
6 · The paper itself

Abstract

Animals learn the value of foods on the basis of their postingestive effects and thereby develop aversions to foods that are toxic

Indexed as

LearningTasteAmygdalaAnimalsFemaleMaleMemoryMental RecallMiceMice, Inbred C57BLNeuronsOptogeneticsTime Factors

Identifiers

PMID40175547
PMCPMC12176619

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.